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IJEB Vol.48(11) [November 2010] >


Title: Antioxidant and hepatoprotective activity of Aphanizomenon flos-aquae Linn against paracetamol intoxication in rats
Authors: Kuriakose, Gini C
Kurup, Muraleedhara G
Keywords: Antioxidants
Aphanizomenon flos-aquae
Hepatoprotection
Paracetamol
Reactive oxygen species
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Paracetamol caused liver damage as evident by significant increase in the activities of aspartate and alanine transferases. There were general statistically significant losses in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione transferase and an increase in thiobarbituric acid reactive substances in the liver of paracetamol treated group compared with the control group. However, treatment with ethanol extract of A. flos-aquae (EEAFA) was able to counteract these effects. Protection offered by silymarin (standard reference drug) seemed relatively greater. The results suggest that EEAFA can act as hepatoprotective agent against paracetamol induced toxicity as an antioxidant.
Page(s): 1123-1130
CC License:  CC Attribution- Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.48(11) [November 2010]

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