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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(11) [November 2010] >
| Title: | Antioxidant and hepatoprotective activity of Aphanizomenon flos-aquae Linn against paracetamol intoxication in rats |
| Authors: | Kuriakose, Gini C
Kurup, Muraleedhara G |
| Keywords: | Antioxidants
Aphanizomenon flos-aquae
Hepatoprotection
Paracetamol
Reactive oxygen species |
| Issue Date: | Nov-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Paracetamol caused liver damage as evident
by significant increase in the activities of aspartate and alanine transferases.
There were general statistically significant losses in the activities of superoxide
dismutase, catalase, glutathione peroxidase and glutathione transferase and an
increase in thiobarbituric acid reactive substances in the liver of paracetamol
treated group compared with the control group. However, treatment with ethanol
extract of A. flos-aquae (EEAFA) was able to counteract these effects.
Protection offered by silymarin (standard reference drug) seemed relatively
greater. The results suggest that EEAFA can act as hepatoprotective agent
against paracetamol induced toxicity as an antioxidant. |
| Page(s): | 1123-1130 |
| CC License: |  CC Attribution- Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(11) [November 2010]
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