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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(11) [November 2010] >
| Title: | Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenum-graecum Linn.) seeds, its purification and effect in diabetes mellitus |
| Authors: | Moorthy, Radha
Prabhu, KM
Murthy, PS |
| Keywords: | Diabetes mellitus
Fenugreek
GII
Intermittent therapy
Trigonella foenum-graecum |
| Issue Date: | Nov-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | An anti-hyperglycemic compound named GII was
purified from the water extract of the seeds of fenugreek (T. foenum-graecum)
and shown to be different from trigonelline and nicotinic acid isolated earlier
from the same plant. GII (50 mg/kg body weight, po) reduced blood glucose in
glucose tolerance test (GTT) in the sub-diabetic and moderately diabetic
rabbits and significantly reduced the area under the curve (AUC) of GTT.
Treatment for 7 days of the sub-diabetic rabbits with GII (50 mg/kg body weight,
po) improved glucose tolerance without reducing fasting blood glucose (FBG)
which was nearly normal. The results suggest that there is no risk of
hypoglycemia in near normal animals (may be humans also) with abnormal GTT.
Treatment of the moderately diabetic rabbits with GII (100 mg/kg body weight for 3 weeks) reduced FBG to nearly normal value
and improved GTT. GII was more effective than the standard drug tolbutamide. Intermittent
therapy given on days 1–5, 11–15, 26–30 and 56–60 to
moderately diabetic rabbits leaving in between days without treatment brought
down FBG to normal and AUC during GTT was normal. After 15 days treatment with
GII (100 mg/kg body weight for 3 weeks) glycosylated hemoglobin came down and
insulin increased to normal values in the sub-diabetic, moderately diabetic and
severely diabetic rabbits. GII treatment (100 mg/kg body weight for 15 days)
brought down all the altered serum lipids
(TC, HDLC, TAG, PLs and FFAs) to
normal levels. The results suggest that intermittent therapy, instead of daily
therapy is possible and GII has good potential as an oral anti-diabetic drug
with intermittent therapy. |
| Page(s): | 1111-1118 |
| CC License: |  CC Attribution- Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(11) [November 2010]
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