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http://nopr.niscair.res.in/handle/123456789/10464
Title: | Effects of IL-18 and IL-10 pre-treatment on the alteration of endogenous cytokines in liver and spleen of mice with experimental endotoxemia |
Authors: | Nandi, Debolina Mishra, Manoj Kumar Basu, Anirban Bishayi, Biswadev |
Keywords: | Anti-oxidant enzymes;Cytokine;Endotoxemia;Lipopolysaccharide;Reactive oxygen species |
Issue Date: | Nov-2010 |
Publisher: | NISCAIR-CSIR, India |
Abstract: | Mechanisms of interleukin-18 (IL-18) and
interleukin-10 (IL-10) in lipopolysaccharide (LPS) induced endotoxemia are not
clear; their protective role is being investigated so that they may effectively
modulate the host cytokine levels during endotoxemia. The aim of the study was
to evaluate protective effects of IL-18 and IL-10 in experimentally induced
endotoxemia in mice correlating the changes in tissue anti-oxidant enzymes and
circulating cytokines. Liver injury was determined by estimation of serum
glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase
(SGPT), serum nitric oxide (NOx), hepatic anti-oxidant enzyme and cytokine
content in LPS (250 ![]() ![]() ![]() ![]() |
Page(s): | 1103-1110 |
URI: | http://hdl.handle.net/123456789/10464 |
ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
Appears in Collections: | IJEB Vol.48(11) [November 2010] |
Files in This Item:
File | Description | Size | Format | |
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IJEB 48(11) 1103-1110.pdf | 237.03 kB | Adobe PDF | View/Open |
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