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Title: Gaso-transmitter hydrogen sulphide: Potential new target in pharmacotherapy
Authors: Gupta, Y K
Dahiya, A K
Reeta, K H
Keywords: Apoptosis
Cardiovascular system
Hydrogen sulphide
Nervous system
Issue Date: Nov-2010
Publisher: NISCAIR-CSIR, India
Abstract: Research in the last two decades has transformed the way hydrogen sulphide (H<sub>2</sub>S) is perceived from a noxious gas to a gaso-transmitter with a vast potential in pharmacotherapy. H<sub>2</sub>S is synthesized in various body-systems using the enzymes cystathionine beta-synthase and cystathionine gamma-lyase; either of these being the predominat enzyme in a particular system. H<sub>2</sub>S may be one of the physiological modulators of blood pressure in humans. The gas relaxes the vascular smooth muscle cells by opening up K<sub>ATP</sub> channels. Moreover, it suppresses the proliferation of vascular smooth muscle cells. H<sub>2</sub>S may also be contributing in the protection afforded by ischaemia-preconditioning. Testosterone is thought to be responsible for the higher central nervous system level of H<sub>2</sub>S in males. In the central nervous system, H<sub>2</sub>S is implicated in Alzheimer’s disease, epilepsy, stroke and Down’s syndrome. Insulin secretion is associated with a decrease in the H<sub>2</sub>S levels. Raised H<sub>2</sub>S is detrimental in acute pancreatitis as well as in septic shock. Recently, H<sub>2</sub>S-releasing derivatives of certain drugs have shown promise in protection against gastric ulcer and in inflammatory bowel disease. The beneficial effects of certain sulphur containing herbs like ginseng and garlic may be mediated via H<sub>2</sub>S. In future, development of specific drugs modulating H<sub>2</sub>S levels may prove beneficial in varied disorders.
Description: 1069-1077
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(11) [November 2010]

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