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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(11) [November 2010] >
| Title: | Gaso-transmitter hydrogen sulphide: Potential new target in pharmacotherapy |
| Authors: | Gupta, Y K
Dahiya, A K
Reeta, K H |
| Keywords: | Apoptosis
Cardiovascular system
Gaso-transmitter
Hydrogen sulphide
Nervous system |
| Issue Date: | Nov-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Research in the last two decades has transformed
the way hydrogen sulphide (H2S) is perceived from a noxious gas to a
gaso-transmitter with a vast potential in pharmacotherapy. H2S is
synthesized in various body-systems using the enzymes cystathionine
beta-synthase and cystathionine gamma-lyase; either of these being the
predominat enzyme in a particular system. H2S may be one of the
physiological modulators of blood pressure in humans. The gas relaxes the
vascular smooth muscle cells by opening up KATP channels. Moreover,
it suppresses the proliferation of vascular smooth muscle cells. H2S
may also be contributing in the protection afforded by ischaemia-preconditioning.
Testosterone is thought to be responsible for the higher central nervous system
level of H2S in males. In the central nervous system, H2S
is implicated in Alzheimer’s disease, epilepsy, stroke and Down’s syndrome.
Insulin secretion is associated with a decrease in the H2S levels.
Raised H2S is detrimental in acute pancreatitis as well as in septic
shock. Recently, H2S-releasing derivatives of certain drugs have
shown promise in protection against gastric ulcer and in inflammatory bowel
disease. The beneficial effects of certain sulphur containing herbs like
ginseng and garlic may be mediated via H2S. In future, development
of specific drugs modulating H2S levels may prove beneficial in
varied disorders. |
| Page(s): | 1069-1077 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(11) [November 2010]
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