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Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.17 [2010] >
IJCT Vol.17(5) [September 2010] >
| Title: | A new method for the spectrophotometric determination of fexofenadine hydrochloride |
| Authors: | Narayana, B
Veena, K |
| Keywords: | Fexofenadine hydrochloride
Spectrophotometry
Chloramine-T
Malachite green
Xylene cyanol FF |
| Issue Date: | Sep-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A novel, sensitive and selective reaction
has been proposed for the assay of fexofenadine hydrochloride (FFH) in bulk and
dosage forms using chloramine-T (CAT) and two dyes malachite green (MAG) and
xylene cyanol FF (XFF). Spectrophotometric method entail the addition of a
known excess of chloramine-T to fexofenadine hydrochloride in hydrochloric acid
medium followed by the determination of residual oxidant by reacting it with a
fixed amount of malachite green, measuring the absorbance at 615 nm (method A),
or xylene cyanol FF, measuring the absorbance at 612 nm (method B). The
apparent molar absorptivities are calculated to be 4.09×104 L mol-1
cm-1, 3.07×104 L mol-1 cm-1 for
method A and B respectively. Both methods are of comparable accuracy and
precision. There is no interference from common additives and excipients. The
method has been applied to the determination of fexofenadine hydrochloride in
pharmaceutical samples and the results are statistically compared with those of
literature UV-spectrophotometric method by applying student’s t-test and F-test. |
| Page(s): | 386-390 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Source: | IJCT Vol.17(5) [September 2010]
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