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Title: Synthesis and in-vitro biological evaluation of some quinazolin substituted pyrazoles, pyrazolones and 1,3,4-oxadiazoles
Authors: Sah, Pramilla
Kaul, Vasudha
Keywords: Quinazolin;pyrazoles;pyrazolones;1,3,4-oxadiazoles;antibacterial;insecticidal
Issue Date: Oct-2010
Publisher: NISCAIR-CSIR, India
Abstract: In the present study, a new series of 1′-[2-phenyl-4-oxo(3H)-quinazolin-3-(benzoyl)/2′′-methylmethine carbonyl)]-3′,5′-dime­thyl pyrazoles 6a,b, 1′-[2-phenyl-4-oxo(3H)-quinazolin-3-(benzo­yl)/2′′-methyl­methine carbonyl)]-3′-methyl-5′(4H)-pyrazolones 7a,b, and [5-(3′-phenyl/methylmethine-2′-phenyl-4′-oxo(3′H)-quinazolin)-2-(4′′-chlorophenyl/3′′,5′′-dinitrophenyl/2′′-nitrophen­yl)]-1,3,4-oxadiazoles 8a,b-10a,b have been synthesized from hydrazides 5a and 5b. These compounds have been characterized by IR, 1H NMR, mass spectra and elemental analysis. These have been screened for their in vitro antibacterial activity against the gram negative strains E. coli and S. aureus by the disc diffusion technique. The insecticidal activity has been tested against the species Callosobruchus chinensis with legume grains as the host
Page(s): 1406-1412
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(10) [October 2010]

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