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Title: Synthesis and <i style="">in-vitro</i> biological evaluation of some quinazolin substituted pyrazoles, pyrazolones and 1,3,4-oxadiazoles
Authors: Sah, Pramilla
Kaul, Vasudha
Keywords: Quinazolin
Issue Date: Oct-2010
Publisher: NISCAIR-CSIR, India
Abstract: In the present study, a new series of 1′-[2-phenyl-4-oxo(3<i style="">H</i>)-quinazolin-3-(benzoyl)/2′′-methylmethine carbonyl)]-3′,5′-dime­thyl pyrazoles <b style="">6a,b</b>, 1′-[2-phenyl-4-oxo(3<i style="">H</i>)-quinazolin-3-(benzo­yl)/2′′-methyl­methine carbonyl)]-3′-methyl-5′(4<i style="">H</i>)-pyrazolones <b style="">7a,b</b>, and [5-(3′-phenyl/methylmethine-2′-phenyl-4′-oxo(3′<i style="">H</i>)-quinazolin)-2-(4′′-chlorophenyl/3′′,5′′-dinitrophenyl/2′′-nitrophen­yl)]-1,3,4-oxadiazoles <b style="">8a,b-10a,b</b> have been synthesized from hydrazides <b style="">5a</b> and <b style="">5b</b>. These compounds have been characterized by IR, <sup>1</sup>H NMR, mass spectra and elemental analysis. These have been screened for their <i style="">in vitro</i> antibacterial activity against the gram negative strains <i style="">E. coli</i> and <i style="">S. aureus</i> by the disc diffusion technique. The insecticidal activity has been tested against the species <i style="">Callosobruchus chinensis</i> with legume grains as the host
Description: 1406-1412
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(10) [October 2010]

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