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Title: Synthesis and antiparkinsonian activity of some new adamantyl thiazolidinonyl/azeti¬dinonyl indole derivatives
Authors: Kumar, Sunil
Kaur, Hemlata
K Saxena, K
Sharma, Monica
Vishwakarma, Pinki
Kumar, Ashok
Keywords: Adamantylthiazolidinonyl indoles
adamantly¬azetidinonyl indoles
antiparkinsonian activity
acute toxicity
Issue Date: Oct-2010
Publisher: NISCAIR-CSIR, India
Abstract: Several 3-adamantylimino-2-(substitutedphenyl)-5-substituted-1H-indoles 1a-h have been prepared by the reaction of various 2-substitutedphenyl-5-substitutedindol-3-aldehydes with amanta­dine. Cycloaddition of 1a-h with thioglycolic acid in presence of anhydrous zinc chloride yielded 3-adamantyl-2-(2-(2-substi­tutedphenyl)-5-substituted-1H-indol-3-yl)thiazolidin-4-ones 2a-h. Compounds 1a-h on reaction with chloro acetyl chloride in presence of triethyl amine give 1-adamantyl-3-chloro-4-(2- (2-substitutedphenyl)-5-substituted-1H-indol-3-yl)azetidin-2-ones 3a-h. Structures of the newly synthesized compounds have been delineated by elemental and spectral (IR, 1H NMR and mass) analysis.
Page(s): 1398-1405
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(10) [October 2010]

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