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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(10) [October 2010] >
| Title: | Synthesis and antiparkinsonian activity of some new adamantyl thiazolidinonyl/azeti¬dinonyl indole derivatives |
| Authors: | Kumar, Sunil
Kaur, Hemlata
K Saxena, K
Sharma, Monica
Vishwakarma, Pinki
Kumar, Ashok |
| Keywords: | Adamantylthiazolidinonyl indoles
adamantly¬azetidinonyl indoles
antiparkinsonian activity
acute toxicity |
| Issue Date: | Oct-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Several
3-adamantylimino-2-(substitutedphenyl)-5-substituted-1H-indoles 1a-h have been
prepared by the reaction of various
2-substitutedphenyl-5-substitutedindol-3-aldehydes with amantadine.
Cycloaddition of 1a-h with
thioglycolic acid in presence of anhydrous zinc chloride yielded
3-adamantyl-2-(2-(2-substitutedphenyl)-5-substituted-1H-indol-3-yl)thiazolidin-4-ones 2a-h. Compounds 1a-h on
reaction with chloro acetyl chloride in presence of triethyl amine give
1-adamantyl-3-chloro-4-(2-
(2-substitutedphenyl)-5-substituted-1H-indol-3-yl)azetidin-2-ones
3a-h. Structures of the newly
synthesized compounds have been delineated by elemental and spectral (IR, 1H
NMR and mass) analysis. |
| Page(s): | 1398-1405 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(10) [October 2010]
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