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dc.contributor.authorShekhawat, Manju-
dc.contributor.authorSingh, P-
dc.contributor.authorKumar, R-
dc.description.abstractThe cyclooxygenase (COX) inhibition activities of the derivatives of 3-phenoxypyran-4-one were analyzed through multiple-regression analysis (MRA). Appropriate physicochemical parameters, identified for the substitutents of phenyl ring, attached to 3-phenoxypyran-4-one moiety were quantitatively correlated with COX-2 and COX-1 inhibition activities of these compounds. The derived significant correlation equation for COX-2 inhibition suggested that the ortho-substituent with negative resonance parameter, the para-substituent with lower dipole moment and the meta-substituent having higher resonance parameter were advantageous for the activity. The derived correlation equation for COX-1 inhibition suggested the significance of resonance effect for ortho-substituents and electron-donating effect for para-substituent. A few potential congeners were also suggested for further synthesis.en_US
dc.sourceIJBB Vol.44(1) [February 2007]en_US
dc.subjectCyclooxygenase-2 inhibitorsen_US
dc.subject3-phenoxypyran-4-one derivativesen_US
dc.subjectQuantitative structure-activity relationshipen_US
dc.titleQuantitative structure-activity relationship study of orally active cyclooxygenase-2 (COX-2) inhibitors of derivatives of 3-phenoxypyran-4-oneen_US
Appears in Collections:IJBB Vol.44(1) [February 2007]

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