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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(10) [October 2010] >
| Title: | Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones |
| Authors: | S Raja, A
K Agarwal, A
Mahajan, N
N Pandeya, S
Ananthan, S |
| Keywords: | Hydrazones
semicarbazones
synthesis
antibacterial
antitubercular |
| Issue Date: | Oct-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Condensation of phenoxy or
4-bromophenoxy acetic
acid hydrazide and substituted aryl
semicarbazides with appropriate carbonyl compounds yield corresponding
hydrazones and semicarbazones, respectively. The chemical structure of the
synthesized compounds has been confirmed by UV, IR and 1H NMR
spectral data. All the compounds have been investigated for their antibacterial
activity against ten pathogenic strains and antitubercular activity against Mycobacterium tuberculosis H37 Rv.
Compound 4f, Acetic acid,
phenoxy-,[1-(4-chlorophenyl) ethylidene] hydrazide has been found to exhibit 80%
inhibition in the preliminary antitubercular screening (MIC >6.25 mg/mL). |
| Page(s): | 1384-1388 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(10) [October 2010]
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