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Title: Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones
Authors: S Raja, A
K Agarwal, A
Mahajan, N
N Pandeya, S
Ananthan, S
Keywords: Hydrazones
Issue Date: Oct-2010
Publisher: NISCAIR-CSIR, India
Abstract: Condensation of phenoxy or 4<i>-</i>bromophenoxy acetic acid hydrazide and substituted<i style=""> </i>aryl semicarbazides with appropriate carbonyl compounds yield corresponding hydrazones and semicarbazones, respectively. The chemical structure of the synthesized compounds has been confirmed by UV, IR and <sup>1</sup>H&nbsp;NMR spectral data. All the compounds have been investigated for their antibacterial activity against ten pathogenic strains<i style=""> </i>and antitubercular activity against <i style="">Mycobacterium tuberculosis </i>H37 Rv. Compound <b>4f</b>, Acetic acid, phenoxy-,[1-(4-chlorophenyl) ethylidene] hydrazide has been found to exhibit 80% inhibition in the preliminary antitubercular screening (MIC &gt;6.25 mg/mL).
Description: 1384-1388
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(10) [October 2010]

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