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IJC-B Vol.49B(10) [October 2010] >


Title: Simple and efficient synthesis of Fmoc/Boc/Cbz-protected-b-amino alcohols and peptidyl alcohols employing Boc2O
Authors: H S, Lalithamba
V Sureshbabu, Vommina
Keywords: Nα-Urethane protected amino acids
-amino alcohols
Boc2O
sodium borohydride
peptidyl alcohols
Issue Date: Oct-2010
Publisher: NISCAIR-CSIR, India
Abstract: An efficient method for the activation of Fmoc/Boc/Cbz-protected amino acids using Boc2O and the reduction of the in situ generated carbonic-carbonic anhydride to their corresponding b-amino alcohols using sodium borohydride has been described. The method is simple, rapid and free from racemization. Besides, the protocol is also extended for the conversion of N-urethane protected peptide acids to their corresponding alcohols.
Page(s): 1372-1378
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(10) [October 2010]

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