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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(10) [October 2010] >
| Title: | Simple and efficient synthesis of Fmoc/Boc/Cbz-protected-b-amino alcohols and peptidyl alcohols employing Boc2O |
| Authors: | H S, Lalithamba
V Sureshbabu, Vommina |
| Keywords: | Nα-Urethane protected amino acids
 -amino alcohols
Boc2O
sodium borohydride
peptidyl alcohols |
| Issue Date: | Oct-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | An efficient method for the activation of
Fmoc/Boc/Cbz-protected amino acids using Boc2O and the reduction of
the in situ generated
carbonic-carbonic anhydride to their corresponding b-amino alcohols using sodium borohydride has been described. The
method is simple, rapid and free from racemization. Besides, the protocol is
also extended for the conversion of N-urethane
protected peptide acids to their corresponding alcohols. |
| Page(s): | 1372-1378 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(10) [October 2010]
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