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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(10) [October 2010] >
| Title: | Localization and characterization of tissue changes by laser backscattering imaging and Monte Carlo simulation |
| Authors: | Pandian, P S
Singh, Megha |
| Keywords: | Monte Carlo simulation
Multi-probe laser reflectometer
Optical parameters
Tissue-equivalent phantoms |
| Issue Date: | Oct-2010 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Laser
backscattering from biological tissues depends on their composition and blood
flow. The onset of the tissue abnormalities is associated with the change in
composition at a specific location which may affect laser backscattering. The
objective of the present work is to detect the compositional changes in
tissue-equivalent phantom of fat, prepared by mixing paraffin wax with wax
colors, and to characterize these in terms of their optical parameters. For
this purpose these phantoms are scanned by a multi-probe non-contact automatic
laser scanning system and images of the normalized backscattered intensity
(NBI) are constructed. By scanning the background subtracted image of the
phantom the location of the abnormality and its size from the full width at
half maximum (FWHM) are determined. The data obtained by ultrasonic technique
for localization of the abnormalities are in agreement with that as obtained by
the present method. The optical parameters of the abnormality are obtained by
matching the measured surface profiles of the abnormality with that of the
profile obtained by Monte Carlo simulation. This analysis shows the possibility
of detection of changes at the onset stage in tissues as required for planning
of the photodynamic therapy. |
| Page(s): | 993-1001 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(10) [October 2010]
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