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Title: An open, prospective, labeled clinical study to evaluate and compare the efficacy of New Rhumatil Gel with Diclofenac Gel on osteoarthritis & other musculo-skeletal conditions
Authors: Dhaniwala, Naresh
Kohli, K R
Sharma, Gaurav
Keywords: Analgesic activity
Anti-inflammatory activity
Musculo-skeletal conditions
Issue Date: Oct-2010
Publisher: NISCAIR-CSIR, India
IPC CodeInt. Cl.8: A61K36/00, A61P19/00, A61P19/02, A61P21/00, A61P29/00
Abstract: Local use of analgesic and anti-inflammatory formulation in different types of arthritis and local pain conditions is an effective and popular route of drug administration with additional usefulness because it avoids first-pass effects, gastrointestinal irritation, and metabolic degradation associated with oral administration of analgesic anti-inflammatory drugs. One such formulation, New Rheumatil Gel was studied for its comparative efficacy with Diclofenac Gel, in clinical trial. In an open labeled, randomized, comparative, prospective study, a total of 100 subjects having pain associated either with osteo-arthritis or musculo-sekeletal conditions were studied, out of these 70 completed the study. The subjects were randomly divided into two groups coded as JPG for New Rheumatil Gel and DCG for Diclofenac Gel. The dose of both drugs was 2 cm gel rubbed gently over affected part twice daily (in the morning and at night). All the subjects were given supportive therapy (calcium, vitamin, etc.) and reviewed at 7 days and 14 days. Their response in pain relief at various activities was noted. After 2 weeks, trial medicines were stopped in both the groups and subjects were again evaluated on 21st day. Statistically, there was no difference observed between the efficacies of both the trial medicines. The onset of analgesic action and its duration was also found to be same in both the groups. However, the overall excellent relief obtained was found to be slightly better in JPG group. When analyzed on the basis of chronicity of condition it was found that new Rheumatil Gel delivered better results in more chronic painful conditions and Diclofenac Gel delivered better in painful conditions of recent onset.
Page(s): 656-659
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Source:IJTK Vol.09(4) [October 2010]

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