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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Traditional Knowledge (IJTK) >
IJTK Vol.09 [2010] >
IJTK Vol.09(4) [October 2010] >
| Title: | An open, prospective, labeled clinical study to evaluate and compare the efficacy of New Rhumatil Gel with Diclofenac Gel on osteoarthritis & other musculo-skeletal conditions |
| Authors: | Dhaniwala, Naresh
Kohli, K R
Sharma, Gaurav |
| Keywords: | Analgesic activity
Anti-inflammatory activity
Ayurveda
Musculo-skeletal conditions
Osteoarthritis
Vata |
| Issue Date: | Oct-2010 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: A61K36/00, A61P19/00, A61P19/02, A61P21/00, A61P29/00 |
| Abstract: | Local use of analgesic and anti-inflammatory formulation in different types
of arthritis and local pain conditions is an effective and popular route of
drug administration with additional usefulness because it avoids first-pass
effects, gastrointestinal irritation, and metabolic degradation associated with
oral administration of analgesic anti-inflammatory drugs. One such formulation,
New Rheumatil Gel was studied for its comparative efficacy with Diclofenac Gel,
in clinical trial. In an open labeled, randomized, comparative, prospective
study, a total of 100 subjects having pain associated either with
osteo-arthritis or musculo-sekeletal conditions were studied, out of these 70
completed the study. The subjects were randomly divided into two groups coded
as JPG for New Rheumatil Gel and
DCG for Diclofenac Gel. The dose of both drugs was 2 cm gel rubbed
gently over affected part twice daily (in the morning and at night). All the
subjects were given supportive therapy (calcium, vitamin, etc.) and reviewed at
7 days and 14 days. Their response in pain relief at various activities was
noted. After 2 weeks, trial medicines were stopped in both the groups and
subjects were again evaluated on 21st day. Statistically, there was
no difference observed between the efficacies of both the trial medicines. The
onset of analgesic action and its duration was also found to be same in both
the groups. However, the overall excellent
relief obtained was found to be slightly better in JPG group. When analyzed
on the basis of chronicity of condition it was found that new Rheumatil Gel
delivered better results in more chronic painful conditions and Diclofenac Gel
delivered better in painful conditions of recent onset. |
| Page(s): | 656-659 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Source: | IJTK Vol.09(4) [October 2010]
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