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|Title:||Investigation on crosslinking density for development of novel interpenetrating polymer network (IPN) based formulation|
Ghosh, Ashoke Kumar
|Keywords:||Controlled release;Crosslinking agent;Interpenetrating polymer network;Microspheres|
|Abstract:||Interpenetrating polymer network (IPN) based formulation, consisting of sodium alginate and poly vinyl alcohol, were prepared by water-in-oil emulsion crosslinking method. IPN based formulation was cross-linked with glutaraldehyde, and loaded with diclofenac sodium (DS) as a model drug. Scanning electron microscopy revealed spherical nature of microspheres (size, 472-157 m). Drug entrapment efficiency (72%) was obtained depending upon concentration of crosslinking density. Novel formulation can be a potential carrier for controlled delivery of short half-lived drugs.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.69(10) [October 2010]|
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