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Title: Investigation on crosslinking density for development of novel interpenetrating polymer network (IPN) based formulation
Authors: Banerjee, Subham
Chaurasia, Gaurav
Pal, Dilipkumar
Ghosh, Ashoke Kumar
Ghosh, Animesh
Kaity, Santanu
Keywords: Controlled release;Crosslinking agent;Interpenetrating polymer network;Microspheres
Issue Date: Oct-2010
Publisher: NISCAIR-CSIR, India
Abstract: Interpenetrating polymer network (IPN) based formulation, consisting of sodium alginate and poly vinyl alcohol, were prepared by water-in-oil emulsion crosslinking method. IPN based formulation was cross-linked with glutaraldehyde, and loaded with diclofenac sodium (DS) as a model drug. Scanning electron microscopy revealed spherical nature of microspheres (size, 472-157 m). Drug entrapment efficiency (72%) was obtained depending upon concentration of crosslinking density. Novel formulation can be a potential carrier for controlled delivery of short half-lived drugs.
Page(s): 777-784
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.69(10) [October 2010]

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