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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.1 [2010] >
IJNPR Vol.1(3) [September 2010] >
| Title: | Diuretic activity of Bixa orellana Linn. leaf extracts |
| Authors: | Radhika, B
Begum, Nasreen
Srisailam, K
Reddy, V M |
| Keywords: | Bixa orellana
Annatto
Soxhlet extraction
Diuretic
Furosemide
Acute toxicity
Arachis oil |
| Issue Date: | Sep-2010 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl.8—A61 K 36/00, A61P 7/12 |
| Abstract: | The present investigation was aimed at investigating the diuretic activity
of Bixa orellana Linn. leaves. The dried leaf powder was subjected to
successive Soxhlet extraction with petroleum ether, chloroform, ethyl acetate,
methanol and water. Among these, petroleum
ether, methanolic and aqueous extracts were investigated for diuretic activity
in Wistar rats using standard methods. The diuretic activity was assessed in
terms of urine output and levels of sodium, potassium and chloride in urine.
The results obtained revealed that the methanolic extract showed significant
diuretic activity at a dose of 500 mg/kg body weight by increasing the total
volume of urine and levels of sodium, potassium and chloride in urine when
compared to standard drug, Furosemide and Arachis oil as control and vehicle for the extracts. |
| Page(s): | 353-355 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Source: | IJNPR Vol.1(3) [September 2010]
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