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Title: Effect of ethanolic extract of Phyla nodiflora (Linn.) Greene against calculi producing diet induced urolithiasis
Authors: Dodoala, Sujatha
Diviti, Ranganayakulu
Koganti, Bharathi
Prasad, K V S R G
Keywords: Antiurolithiatic activity;Calcium oxalate;Renal stones;Calculi producing diet;Phyla nodiflora;Urolithiasis
Issue Date: Sep-2010
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl.8 - A61K 36/00, A61P 13/04
Abstract: Urolithiasis in its different forms is a frequently encountered urological disorder. For many years it has been at the forefront of urology. In the present study ethanolic extract of whole plant of Phyla nodiflora (Linn.) Greene was studied for its antiurolithiatic activity against most common type of renal stones i.e. calcium oxalate type. Calcium oxalate urolithiasis was induced by administration of Gentamycin and calculi producing diet (5% ammonium oxalate in standard rat pellet feed). The extract was also assessed for effect on in vivo antioxidant parameters like lipid peroxidation, reduced glutathione, catalase in hyperoxaluric kidney and in vitro scavenging of nitric oxide and 2-diphenyl-2-picryl hydrazyl free radicals. Ethanolic extract of P. nodiflora exhibited significant effect in preventing calcium oxalate stone formation and also in dissolving the pre-formed calcium oxalate stones in the kidney along with significant effect on both in vitro and in vivo antioxidant parameters. The present study clearly demonstrates the antiurolithiatic activity of P. nodiflora supporting the traditional claim.
Page(s): 314-321
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.1(3) [September 2010]

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