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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.1 [2010] >
IJNPR Vol.1(3) [September 2010] >
| Title: | Effect of ethanolic extract of Phyla nodiflora (Linn.) Greene against calculi producing diet induced urolithiasis |
| Authors: | Dodoala, Sujatha
Diviti, Ranganayakulu
Koganti, Bharathi
Prasad, K V S R G |
| Keywords: | Antiurolithiatic activity
Calcium oxalate
Renal stones
Calculi producing diet
Phyla nodiflora
Urolithiasis |
| Issue Date: | Sep-2010 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl.8 - A61K 36/00, A61P 13/04 |
| Abstract: | Urolithiasis in its different forms is a frequently encountered urological
disorder. For many years it has been at the forefront of urology. In the
present study ethanolic extract of whole plant of Phyla nodiflora (Linn.)
Greene was studied for its
antiurolithiatic activity against most common type of renal stones i.e. calcium
oxalate type. Calcium oxalate urolithiasis was induced by administration of
Gentamycin and calculi producing diet (5% ammonium oxalate in standard rat
pellet feed). The extract was also assessed for effect on in vivo
antioxidant parameters like lipid peroxidation, reduced glutathione, catalase
in hyperoxaluric kidney and in vitro scavenging of nitric oxide and
2-diphenyl-2-picryl hydrazyl free radicals. Ethanolic extract of P. nodiflora exhibited significant
effect in preventing calcium oxalate stone formation and also in dissolving the
pre-formed calcium oxalate stones in the kidney along with significant effect
on both in vitro and in vivo antioxidant parameters. The
present study clearly demonstrates the antiurolithiatic activity of P. nodiflora supporting the traditional
claim. |
| Page(s): | 314-321 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Source: | IJNPR Vol.1(3) [September 2010]
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