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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(09) [September 2010] >
| Title: | Synthesis and biological screening of 7-alkyl-3,3a,4,5-tetrahydroisoxazolo[3,4-d]pyridazines and 3-chloromethyl-7-methyl-3a,4-dihydro-3H-isoxazolo[3,4-d][1,2]oxazine |
| Authors: | Naqvi, Tahira
Kapoor, Kamal K
Sharma, Rattan Lal |
| Keywords: | 2-Isoxazolines
pyridazine
[1,2]oxazine
isoxazolopyridazine
isoxazolo[1,2]oxazine |
| Issue Date: | Sep-2010 |
| Publisher: | CSIR |
| Abstract: | Novel
3-acyl-4-bromomethyl- and 3-acyl-4,5-bischloromethyl-2-isoxazolines have been
prepared from alkenes like allyl bromide and 1,4-dichloro-trans-2-butene respectively and methyl ketones using Fe(NO3)3.9H2O.
Further, 7-alkyl-3,3a,4,5-tetrahydroisoxazolo[3,4-d]pyridazines and
3-chloromethyl-7-methyl-3a,4-dihydro-3H-isoxazolo[3,4-d][1,2]oxazine have been prepared from all these 2-isoxazolines and
3-acetyl-4,5-bischloromethyl-2-isoxazoline respectively by their reaction with
hydrazines and hydroxylamine respectively. These compounds have been obtained
either as racemic-mixture or mixture of four diastereoisomers (two pairs of
racemates) and are characterised by their elemental analysis and spectral
studies. These compounds have been put to screening for antifungal and anti
bacterial activity and the results have been found highly promising. |
| Page(s): | 1282-1289 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(09) [September 2010]
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