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|Title:||A green approach to chemoselective N-acetylation of amines using catalytic amount of zinc acetate in acetic acid under microwave irradiation|
|Keywords:||Microwave irradiation;amines;acetic acid;zinc acetate;N-acetylation;chemoselectivity|
|Abstract:||It has been found for the first time that zinc acetate alone can act as a selective N-acetylating agent without any solvent under closed vessel microwave irradiation. It is also observed that the use of a catalytic amount of this reagent in acetic acid is sufficient enough for smooth running of N-acetylation of a number of structurally diverse amines, and the reaction is chemoselective with respect to phenols, thiols, acids and alcohols. Herein is reported a simple, efficient, cost-effective and environmentally benign alternative method for chemoselective N-acetylation of amines using catalytic amount of zinc acetate in acetic acid under microwave irradiation. The reaction procedure requires no other solvent, and is rapid with good to excellent yields.|
|Appears in Collections:||IJC-B Vol.49B(09) [September 2010]|
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