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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(09) [September 2010] >
| Title: | Synthesis and antimicrobial activity of 1-alkyl and aryl-3-(2-methyl-1,8-naphthyridin-3-yl)ureas |
| Authors: | Ramesh, D
Chary, M Thirumala
Laxminarayana, E
Sreenivasulu, B |
| Keywords: | 1,8-naphthyridines
carbohydrazide
Curtius rearrangement
microbial activity
glass slide humid chamber technique |
| Issue Date: | Sep-2010 |
| Publisher: | CSIR |
| Abstract: | 1,8-naphthyridine
derivatives have attracted considerable attention because they are the chief
constituent of many compounds which have been isolated from natural sources,
with various biological activities. Nalidixic acid, for example, possesses
strong antibacterial activity and used mainly for the treatment of urinary
tract infections with gram negative pathogens and Gemifloxacin has
antimicrobial and antibacterial activities. It is known that (E)-
and (Z)-o-(diethylamino)ethyl oximes of 1,8-naphthyridine series
have the potential for use as local anesthetics and
1-(2-fluorobenzyl)-3-(2-tolyl)-1,8-naphthyridin-2(1H)-one is used for
the treatment of memory disorders, in particular, Alzheimer’s disease. In
recent years, research on derivatives of 1,8-naphthyridine has been intensive
because these compounds show a wide range of biological activities.
2-Methyl-1,8-naphthyridine-3-carbonylazide has been synthesized from
ethyl-2-methyl-1,8-naphthyridine-3-carboxylate following two different
procedures. The azide on heating with aliphatic and aromatic primaryamines in
xylene underwent Curtius rearrangement to furnish the title compounds. They
have been screened for their antimicrobial activity. |
| Page(s): | 1271-1273 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(09) [September 2010]
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