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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(09) [September 2010] >
| Title: | Synthesis and biological evaluation of some hydrazones and carbazones of indane-1,3-dione |
| Authors: | Jubie, S
Meena, S
Ramaseshu, K V
Jawahar, N
Vijayakumar, S |
| Keywords: | Indane-1,3-dione
hydrazones
carbazones |
| Issue Date: | Sep-2010 |
| Publisher: | CSIR |
| Abstract: |
Diethyl phthalate on
treatment with ethyl acetate in sodium ethoxide gives sodium salt of ester
derivative, which on neutralization in presence of sulphuric acid affords indane-1,3-dione 1. Various hydrazines and carbazides on condensation with 1 in
ethanol under reflux furnish the corresponding hydrazones and carbazones 2a-g. The structures of the compounds
have been established by IR and 1H NMR spectral data. All the
synthesized compounds have been evaluated for their anticoagulant and
antimicrobial activities. Among these, compounds 2b and 2c have shown
significant anticoagulant activity. All the compounds exhibited mild to
moderate antimicrobial activities. Among these compounds 2a and 2g are found to
have antimicrobial activities comparable to that of standard drugs used. |
| Page(s): | 1261-1263 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(09) [September 2010]
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