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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(09) [September 2010] >
| Title: | Fungitoxicity and QSAR of 4-amino-5-substituted aryl-3- mercapto-(4H)-1,2,4-triazoles |
| Authors: | Bijul, Lakshman A
Gupta, R L |
| Keywords: | QSAR
1,2,4-triazoles
fungicidal activity
agrochemicals |
| Issue Date: | Sep-2010 |
| Publisher: | CSIR |
| Abstract: | Twenty eight 4-amino-5-substituted
aryl-3-mercapto-1,2,4-triazoles have been tested in vitro against Rhizoctonia
solani, Sclerotium rolfsii, Fusarium oxysporum, Pythium aphanidermatum,
Puccinia recondita and Bipolaris sorokiniana. These triazoles have
shown very good activity against all the six test fungi, their activity against
P. recondita and B. sorokiniana have been found excellent.
The compound, 5-(2-chloro-5-nitrophenyl)-4-amino-3-mercapto-1,2,4-triazole 27 exhibits highest activity (ED50
=12 mg mL-1) against
P. recondita and the compounds
5-(2-chlorophenyl)-4-amino-3-mercapto-1,2,4-triazole 3 and 5-(4-formylphenyl)-4-amino-3-mercapto-1,2,4-traizole 19 (ED50 =27 mg mL-1) against B.
sorokiniana. The quantitative structure activity
relationship (QSAR) analyzed using physicochemical parameters for hydrophobic,
electronic and steric properties of the molecules by means of multiple
regression analysis has revealed different
structural requirement for fungicidal activity against different fungi.
The position dependent steric effect of the aryl substituents is playing an
important role in imparting fungicidal activity against all the test fungi. The
positive sign with steric parameter terms indicate that their higher values
enhance the fungicidal activity in this series. The other parameters for
hydrophobic and electronic effect are also influencing the fungicidal activity
differently against different fungi. |
| Page(s): | 1235-1242 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(09) [September 2010]
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