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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(4) [August 2010] >
| Title: | Dietary restriction prevents diabetogenic effect of streptozotocin in mice |
| Authors: | Goyary, D
Sharma, R |
| Keywords: | Dietary restriction
Ad libitum
Streptozotocin
Diabetes
Mice |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: |
The beneficial role of dietary restriction (DR) was studied in
streptozotocin (STZ)-induced diabetes in mice. The DR mice exhibited the lower blood
glucose (mg/dl) level as compared to
ad libitum (AL) fed ones. After 3 months’ DR, STZ treatment
to both AL
and DR mice showed significant (p<0.001) elevation of the blood glucose
level in AL-fed mice, while a lower level of glucose was maintained in DR-fed
mice. The ability of maintaining a low blood glucose level in STZ-treated DR mice
indicated that STZ might have been ineffective from its action on beta cells of
pancreas by long-term DR. Thus, these findings suggested
that DR may be an important tool for preventing the diabetic
conditions. However, further studies are required to know the mechanism(s) of
DR protection against diabetogenic action of STZ in experimental animals. |
| Page(s): | 254-256 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(4) [August 2010]
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