|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.47 [2010] >
IJBB Vol.47(4) [August 2010] >
| Title: | Anti-hyperglycemic and anti-oxidative effect of aqueous extract of Momordica charantia pulp and Trigonella foenum graecum seed in alloxan-induced diabetic rats |
| Authors: | Tripathi, Uma Nath
Chandra, Deepak |
| Keywords: | Alloxan
Diabetic rat
Anti-oxidative effect
Momordica charantia
Trigonella foenum graecum
Anti-hyperglycemic activity |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | Diabetes is an oxidative stress disorder and oxidative damage to tissues
such as heart, kidney, liver and other
organs may be a contributory factor to several diabetic complications. Momordica charantia (family:
Cucurbitaceae) and Trigonella foenum
graecum (family:
Fabaceae)
are used traditionally in Indian folk medicine to manage diabetes mellitus. In
the present study, the anti-hyperglycemic and anti-oxidative potential of
aqueous extracts of M. charantia pulp
and seed powder of T. foenum graecum
were assessed in alloxan (150 mg/kg body weight) induced diabetic rats. Alloxan
treatment to the rats could induce diabetes as the fasting blood glucose (FBG)
levels were >280 mg/dl. Treatment of diabetic rats for
30 days with M. charantia and T. foenum graecum could significantly (p<0.001)
improve the FBG levels to
near normal glucose levels. Antioxidant activities (superoxide dismutase,
catalase, reduced glutathione content and glutathione-s-transferase) and lipid
peroxidation levels were measured in heart, kidney and liver tissues of normal,
diabetic and experimental animals (diabetics + treatment). TBARS levels were
significantly (p<0.001) higher and anti-oxidative activities were
found low in diabetic group, as compared to the control group. Significant (p<0.001)
improvement in both the TBARS levels and antioxidant activities were observed
when M. charantia and T. foenum graecum were given to diabetic
rats. Our results clearly demonstrate that M.
charantia and T. foenum graecum
are not only useful in controlling the blood glucose levels, but also have
antioxidant potential to protect vital organs such as heart and kidney against
damage caused due to diabetes induced oxidative stress. |
| Page(s): | 227-233 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.47(4) [August 2010]
|
|
