Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/101
Title: Exploring QSAR of peripheral benzodiazepine receptor binding affinity of N,N-dialkyl-2-phenylindol -3-yl-glyoxylamides using physico-chemical descriptors
Authors: Roy, Kunal
Dalai, Manoj Kumar
Keywords: QSAR
Peripheral benzodiazepine receptor
N,N-Dialkyl-2-phenylindol-3-yl-glyoxylamides
Physico-chemical descriptors
Binding affinity
Issue Date: Apr-2007
Publisher: CSIR
Abstract: The present QSAR study has attempted to explore the structural and physicochemical requirements of ligands N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for binding with peripheral benzodiazepine receptor (PBR). The calcu¬lated partition coefficient values show parabolic relations with the PBR binding affinity, suggesting that the binding affinity increases with increase in the partition coefficient of the compounds until it reaches the critical value after which the affinity decreases. The critical value of logP is within range of 6.052-6.410. Furthermore, positive Wang-Ford charge values of carbonyl oxygens of the glyoxamide moiety and negative Wang-Ford charge value of the glyoxamide nitrogen are conducive for the binding affinity. Again, the indole moiety should have favorable charge distribution. Higher values of the parameters dipole moment (Dipole) and moment of inertia (I_z) of the ligands are conducive for the binding affinity. The presence of hydrogen atom at R₂ and cyclic moiety at R₁ and R₂ positions are detrimental to the binding affinity.
Description: 114-121
URI: http://hdl.handle.net/123456789/101
ISSN: 0301-1208
Appears in Collections:IJBB Vol.44(2) [April 2007]

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