|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(09) [September 2010] >
| Title: | Antinociceptive activity of chronic administration of different extracts of Terminalia bellerica Roxb. and Terminalia chebula Retz. fruits |
| Authors: | Kaur, Sarabjit
Jaggi, R K |
| Keywords: | Antinociceptive
Ethanol extract
Terminalia bellerica
Terminalia chebula |
| Issue Date: | Sep-2010 |
| Publisher: | CSIR |
| Abstract: | The petroleum ether (PE), chloroform (CH), ethanol (ETH) and water extracts
of Terminalia bellerica and T. chebula fruits were evaluated for
their analgesic activity using the tail immersion model in mice. The ethanolic
extracts of both the plants exhibited analgesic response at 200,400 and
800mg/kg. The studies were further carried for 15 days to evaluate the effect
of these extracts in chronic pain and maximum analgesic response was observed
on 14th day in both the plants. Phytochemical investigation of
ethanolic extract of the fruits of Terminalia
bellerica and T. chebula revealed
the presence of saponins, triterpenoids, carbohydrates, tannins and proteins.
The results indicate that fruits of T.
bellerica and T. chebula could be
considered as potential candidate for bioactivity-guided isolation of natural
analgesic agents used in the management of chronic pain. |
| Page(s): | 925-930 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(09) [September 2010]
|
|
