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Title: Cardioprotection by <i style="">Inula racemosa </i>Hook in experimental model of myocardial ischemic reperfusion injury
Authors: Ojha, Shreesh
Nandave, Mukesh
Kumari, Santosh
Arya, Dharamvir S
Keywords: Cardioprotection
<i style="">Inula racemosa</i>
Myocardial infarction
Issue Date: Sep-2010
Publisher: CSIR
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"> To evaluate the cardioprotective potential of <i style="">Inula racemosa</i> in myocardial ischemic-reperfusion injury, Wistar male albino rats were randomly divided into four groups. The group I and II animals were administered saline orally {(sham, ischemia- reperfusion (I-R) control group)} and animals of group III and group IV received <i style="">I.</i><i style=""> racemosa</i> extract (100 mg/kg) for 30 days. On the 30<sup>th</sup> day, animals of I-R control and <i style="">I.</i><i style=""> racemosa</i> treated groups were underwent 45 min of ligation of left anterior descending coronary artery and were thereafter re-perfused for 60 min. In the I-R control group, a significant decrease of mean arterial pressure (MAP), heart rate (HR), contractility, (+)LVdP/dt and relaxation, (-)LVdP/dt and an increase of left ventricular end diastolic pressure (LVEDP) were observed. Subsequent to haemodynamic impairment and left ventricular contractile dysfunction, a significant decline was observed in endogenous myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH). Increased lipid peroxidation characterized by malonaldialdehyde (MDA) formation along with depletion of cardiomyocytes specific enzymes, creatine phosphokinase-MB (CK-MB) isoenzyme and lactate dehydrogenase (LDH) in I-R control group compared to sham group revealed I-R injury of heart. However, treatment with <i style="">I. racemosa</i> significantly restored the myocardial antioxidant status evidenced by increased SOD, CAT, GPx and GSH and prevented leakage of cardio-specific enzymes; CK-MB and LDH and favorably modulated the altered MAP, HR, (+)LVdP/dt, (-)LVdP/dt and LVEDP as compared to I-R control. Furthermore, I-R induced lipid peroxidation was significantly inhibited by <i style="">I.</i><i style=""> racemosa</i> treatment. These beneficial cardioprotective effects translated into significant improvement in cardiac function. In conclusion, our study has demonstrated that the cardioprotective effect of <i style="">I.</i><i style=""> racemosa</i> likely resulted to improved antioxidant status, haemodynamic and left ventricular contractile function subsequent to suppression of oxidative stress</smarttagtype>
Description: 918-924
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(09) [September 2010]

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