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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(09) [September 2010] >
| Title: | Therapeutic effect of ethanolic extract of Hygrophila spinosa T. Anders on gentamicin-induced nephrotoxicity in rats |
| Authors: | Bibu, K J
Joy, A D
Mercey, K A |
| Keywords: | Free radical scavenging
Gentamicin
Hygrophila spinosa
Therapeutic |
| Issue Date: | Sep-2010 |
| Publisher: | CSIR |
| Abstract: | Therapeutic effect of ethanolic extract of Hygrophila spinosa in gentamicin-induced nephrotoxic model of
kidney injury in male Sprague-Dawley rats was studied. Rats were administered
with gentamicin at a dose of 80 mg/kg intraperitoneally (ip) to induce
nephrotoxicity. Kidney function was assessed by measuring serum creatinine and
urea. Kidney superoxide dismutase, lipid peroxidation, catalase and reduced
glutathione were also measured in control and treated rats.
H. spinosa extract showed free
radical scavenging activities at doses of 50 and 250 mg/kg with a predominant
activity at
250 mg/kg. The ethanolic extract also caused a reduction in serum creatinine
and urea levels. Histopathological studies were conducted to confirm the
therapeutic action of the plant extract. The results demonstrated that the
ethanolic extract of whole plant of H.
spinosa evinced the therapeutic effect and inhibited gentamicin-induced
proximal tubular necrosis. |
| Page(s): | 911-917 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(09) [September 2010]
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