Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/10095
Title: Hepatoprotective properties of <i>Caesalpinia sappan </i>Linn. heartwood on carbon tetrachloride induced toxicity
Authors: Srilakshmi, V Sathya
Vijayan, P
Raj, P Vasanth
Dhanaraj, S A
Chandrashekhar, H Raghu
Keywords: <i>Caesalpinia sappan</i>
Heartwood
Hepatocytes
Hepatoprotective
Issue Date: Sep-2010
Publisher: CSIR
Abstract: Aim of the study was to investigate the methanol and aqueous extracts of heartwood of <i>C. sappan </i>for its hepatoprotective activity against CCl<sub>4</sub> induced toxicity in freshly isolated rat hepatocytes and animals. Freshly isolated rat hepatocytes were exposed to CCl<sub>4</sub> (1%) along with/without various concentrations of methanolic and aqueous extract of <i>C. sappan</i> (1000-800 µg/ml) and the levels of selected liver enzymes were estimated. Antihepatotoxic effect of methanolic extract was observed in freshly isolated rat hepatocytes at concentrations 1000-800 µg/ml and was found to be similar to that of standard drug silymarin. Wistar strain albino rat model was used for the investigation of <i style="">in vivo </i>hepatoprotective properties of aqueous and methanolic extract of <i style="">C. sappan </i>(100 and 200 mg/kg body weight). Liver damage was induced by ip administration of CCl<sub>4 </sub>(30%) suspended in olive oil (1 ml/kg body weight). Both the tested extracts showed potent hepatoprotective activity at 200 mg/kg body weight test dose which was comparable with that of the standard silymarin used in similar test dose. The methanolic and aqueous extract was able to restore the biochemical levels to normal which were altered due to CCl<sub>4</sub> intoxication in freshly isolated rat hepatocytes and also in animals.
Description: 905-910
URI: http://hdl.handle.net/123456789/10095
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(09) [September 2010]

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