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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(09) [September 2010] >
| Title: | Antioxidant and hepatoprotective effect of the ethyl acetate extract of Enicostemma axillare (Lam). Raynal against CCl4-induced liver injury in rats |
| Authors: | Jaishree, V
Badami, Shrishailappa
Krishnamurthy, Praveen Thaggikuppe |
| Keywords: | Antioxidant
Enicostemma axillare
Gentianaceae
Liver protection |
| Issue Date: | Sep-2010 |
| Publisher: | CSIR |
| Abstract: |
Enicostemma axillare is used in Indian
traditional medicine as a liver tonic. Its ethyl acetate extract has shown
potent in vitro antioxidant activity and found to contain 7.26% of a
bitter secoiridoid glycoside, swertiamarin. Hence, in the present study the
ethyl acetate extract was screened for hepatoprotective and antioxidant
properties against CCl4 induced hepatic injury in rats. The
hepatoprotection was assessed in terms of reduction in histological damage and
changes in serum enzymes and metabolites. The pretreatment with the extract at
100 and 200 mg/kg body weight doses given orally for eight days prior to CCl4
caused significant restoration of altered biochemical changes due to CCl4
towards the normal in serum, liver and kidney. The extract treatment at 200
mg/kg body weight was found to be more potent than the standard silymarin at
100 mg/kg body weight in reversing most of the biochemical parameters.
Histopathological studies complemented the results of biochemical estimations
in providing a proof of hepatoprotective and antioxidant actions of the
extract. The study provides a support to the ethnomedical use of E. axillare
in India. |
| Page(s): | 896-904 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(09) [September 2010]
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