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Title: Synthesis and anti-microbial activity of (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxoindolin-3-ylidene) semicarbazide and its derivatives
Authors: Basavarajaiah, S M
Mruthyunjayaswamy, B H M
Keywords: Thiazole
Schiff base
anti-microbial activity
Issue Date: Aug-2010
Publisher: CSIR
Abstract: 3-[(2S)-3-Acetyl-5-amino-N-(4-substituted-thiazol-2-yl)2,3-dihydro-1,3,4-oxadiazol-2-yl]-indolin-2-yl acetates, 1-{N-[(2R)-2-(-2-oxoindolin-3-ylidene)-4-oxo-1,3-thiazolidin-3-yl]-3-(4-substituted-thiazol-2yl)ureas, N-(4-substituted-thiazol-2-yl)-[1,3,4]-oxadiazino[6,5]indol-3-amines and (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxo-1-(substituted) methyl)indolin-3-ylidene)semicarbazides have been prepared by making use of (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxoindolin-3-ylidene) semicarbazides obtained by the reaction of (4-substituted thiazole-2-yl) semicarbazides and isatin. The structures of the newly synthesized compounds have been confirmed on the basis of analytical, IR, 1H NMR and mass spectral data. The newly synthesized compounds have been screened for their antimicrobial activities.
Page(s): 1117-1126
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(08) [August 2010]

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