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Title: Synthesis of a new series of quinolinyl chalcones as anticancer and anti-inflammatory agents
Authors: Kotra, Vijay
Ganapaty, S
Adapa, Srinivas R
Keywords: Quinolinyl chalcones
anticancer activity
anti-inflammatory activity
Issue Date: Aug-2010
Publisher: CSIR
Abstract: A new series of quinolinyl chalcone derivatives (SGCH 1-20) have been synthesized by the reaction of quinolinyl and chloroquinolinyl acetophenones with substituted aromatic aldehydes. These compounds have been characterized by IR, 1H NMR, mass spectral and elemental analysis. The compounds have been found to exhibit anticancer and anti-inflammatory activities. Among the compounds tested for anticancer activity on RAW cell lines by MTT assay, compound SGCH 3 (3-(4-chlorophenyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one) show more percentage of inhibition upto 103%. With regard to the anti-inflammatory activity, compound SGCH 9 (3-(2-furyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one), SGCH 10 (3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one), SGCH 19 (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-furyl)-2-propen-1-one) and SGCH 20 (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one) have been found to significant reduction in rat paw oedema when compared to the other compounds.
Description: 1109-1116
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(08) [August 2010]

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