Synthesis of a new series of quinolinyl chalcones as anticancer and anti-inflammatory agents

Abstract

A new series of quinolinyl chalcone derivatives (<b>SGCH 1-20</b>) have been synthesized by the reaction of quinolinyl and chloroquinolinyl acetophenones with substituted aromatic aldehydes. These compounds have been characterized by IR, ¹H NMR, mass spectral and elemental analysis. The compounds have been found to exhibit anticancer and anti-inflammatory activities. Among the compounds tested for anticancer activity on RAW cell lines by MTT assay, compound <b style="">SGCH 3</b> (3-(4-chlorophenyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one) show more percentage of inhibition upto 103%. With regard to the anti-inflammatory activity, compound <b style="">SGCH 9</b> (3-(2-furyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one), <b style="">SGCH 10</b> (3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one), <b style="">SGCH 19</b> (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-furyl)-2-propen-1-one) and <b style="">SGCH 20</b> (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one) have been found to significant reduction in rat paw oedema when compared to the other compounds.