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Title: Synthesis of a new series of quinolinyl chalcones as anticancer and anti-inflammatory agents
Authors: Kotra, Vijay
Ganapaty, S
Adapa, Srinivas R
Keywords: Quinolinyl chalcones
anticancer activity
anti-inflammatory activity
Issue Date: Aug-2010
Publisher: CSIR
Abstract: A new series of quinolinyl chalcone derivatives (<b>SGCH 1-20</b>) have been synthesized by the reaction of quinolinyl and chloroquinolinyl acetophenones with substituted aromatic aldehydes. These compounds have been characterized by IR, <sup>1</sup>H NMR, mass spectral and elemental analysis. The compounds have been found to exhibit anticancer and anti-inflammatory activities. Among the compounds tested for anticancer activity on RAW cell lines by MTT assay, compound <b style="">SGCH 3</b> (3-(4-chlorophenyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one) show more percentage of inhibition upto 103%. With regard to the anti-inflammatory activity, compound <b style="">SGCH 9</b> (3-(2-furyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one), <b style="">SGCH 10</b> (3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one), <b style="">SGCH 19</b> (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-furyl)-2-propen-1-one) and <b style="">SGCH 20</b> (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one) have been found to significant reduction in rat paw oedema when compared to the other compounds.
Description: 1109-1116
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(08) [August 2010]

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