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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(08) [August 2010] >
| Title: | Synthesis of a new series of quinolinyl chalcones as anticancer and anti-inflammatory agents |
| Authors: | Kotra, Vijay
Ganapaty, S
Adapa, Srinivas R |
| Keywords: | Quinolinyl chalcones
anticancer activity
anti-inflammatory activity |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Abstract: | A new series of quinolinyl chalcone derivatives
(SGCH 1-20) have been synthesized by the reaction of quinolinyl and chloroquinolinyl acetophenones
with substituted aromatic aldehydes. These
compounds have been characterized by IR, 1H NMR, mass spectral
and elemental analysis. The compounds have been found to exhibit anticancer and
anti-inflammatory activities. Among the compounds tested for anticancer
activity on RAW cell lines by MTT assay, compound SGCH 3 (3-(4-chlorophenyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one)
show more percentage of inhibition upto 103%. With regard to the
anti-inflammatory activity, compound SGCH
9 (3-(2-furyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one), SGCH 10 (3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one),
SGCH 19 (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-furyl)-2-propen-1-one)
and SGCH 20 (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one)
have been found to significant reduction in rat paw oedema when compared to the
other compounds. |
| Page(s): | 1109-1116 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.49B(08) [August 2010]
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