NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(08) [August 2010] >


Title: 1,3-Di-peptido-conjugates of calix[4]arene and its di-OCH3 derivatives: Synthesis, characterization and phosphate recognition
Authors: Dey, Mishtu
Ali, Amjad
Acharya, Amitabha
Rao, Chebrolu P
Keywords: Peptido-conjugates of calix[4]arene
HMQC
binding core
conformational mobility
phosphate binding
Issue Date: Aug-2010
Publisher: CSIR
Abstract: Novel double-armed peptido-conjugates of calix[4]arene have been developed on the lower rim of the macrocycle. The functional group pendants exhibit conformational bend through the involvement of 11-atom N-H…O hydrogen bond inscribed in a 14-atom O-H…O interaction. As a result, only the terminal -COOR and -COOH groups are exposed to the environment, but not the amide moiety. The cone-conformation of the calix[4]arene is further stabilized through the O-H…O interactions at the lower rim. In effect, the conjugates exhibit a binding core at the lower rim along with hydrophobic cavity formed by the enclosure of arene moieties. Conformational mobility induced by the replacement of lower rim phenolic–OH by –OCH3 has also been demonstrated by variable temperature NMR studies in case of the corresponding –OCH3 derivatives. Differential receptor binding characteristics of these conjugates towards phosphate are demonstrated using absorption spectroscopy. The negatively charged phosphate group is received preferentially by the carboxylic terminal over the ester terminal conjugate.
Page(s): 1098-1108
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(08) [August 2010]

Files in This Item:

File Description SizeFormat
IJCB 49B(8) 1098-1108.pdf807.77 kBAdobe PDFView/Open
 Current Page Visits: 870 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 509412 since 06-Feb-2009  Last updated on 11-Apr-2014Webmaster: nopr@niscair.res.in