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IJC-B Vol.49B [2010] >
IJC-B Vol.49B(08) [August 2010] >


Title: Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles
Authors: Shailaja, M
Anitha, M
Manjula, A
Rao, B Vittal
Keywords: 1,3,4-Oxadiazoles
chloramine-T
oxidative cyclization
halopyridines
Issue Date: Aug-2010
Publisher: CSIR
Abstract: A new and previously unreported molecular framework of 1,3,4-oxadiazoles incorporating halo pyridines has been synthesised. The derivatives are synthesised starting from substituted pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene hydrazides followed by chloramine-T oxidation to the title compounds. The 2,5-disubstituted 1,3,4-oxadiazole derivatives are tested for antimicrobial activity. Many compounds showed high degree of activity against Staphylococus aureus and Escherichia coli bacteria at 250 g/mL concentration.
Page(s): 1088-1097
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.49B(08) [August 2010]

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