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|Title:||Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles|
Rao, B Vittal
|Abstract:||A new and previously unreported molecular framework of 1,3,4-oxadiazoles incorporating halo pyridines has been synthesised. The derivatives are synthesised starting from substituted pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene hydrazides followed by chloramine-T oxidation to the title compounds. The 2,5-disubstituted 1,3,4-oxadiazole derivatives are tested for antimicrobial activity. Many compounds showed high degree of activity against <i style="">Staphylococus aureus</i> and <i style="">Escherichia coli</i> bacteria at 250 <img src='/image/spc_char/micro.gif' border=0>g/mL concentration.|
|Appears in Collections:||IJC-B Vol.49B(08) [August 2010]|
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