Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/10080
Title: Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles
Authors: Shailaja, M
Anitha, M
Manjula, A
Rao, B Vittal
Keywords: 1,3,4-Oxadiazoles
chloramine-T
oxidative cyclization
halopyridines
Issue Date: Aug-2010
Publisher: CSIR
Abstract: A new and previously unreported molecular framework of 1,3,4-oxadiazoles incorporating halo pyridines has been synthesised. The derivatives are synthesised starting from substituted pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene hydrazides followed by chloramine-T oxidation to the title compounds. The 2,5-disubstituted 1,3,4-oxadiazole derivatives are tested for antimicrobial activity. Many compounds showed high degree of activity against <i style="">Staphylococus aureus</i> and <i style="">Escherichia coli</i> bacteria at 250 <img src='/image/spc_char/micro.gif' border=0>g/mL concentration.
Description: 1088-1097
URI: http://hdl.handle.net/123456789/10080
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.49B(08) [August 2010]

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