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|Title:||Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles|
Rao, B Vittal
|Abstract:||A new and previously unreported molecular framework of 1,3,4-oxadiazoles incorporating halo pyridines has been synthesised. The derivatives are synthesised starting from substituted pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene hydrazides followed by chloramine-T oxidation to the title compounds. The 2,5-disubstituted 1,3,4-oxadiazole derivatives are tested for antimicrobial activity. Many compounds showed high degree of activity against Staphylococus aureus and Escherichia coli bacteria at 250 g/mL concentration.|
|Appears in Collections:||IJC-B Vol.49B(08) [August 2010]|
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|IJCB 49B(8) 1088-1097.pdf||130.06 kB||Adobe PDF||View/Open|
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