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Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.49A [2010] >
IJC-A Vol.49A(08) [August 2010] >
| Title: | Interaction of DNA with small molecules: Role of copper histidyl peptide complexes in DNA binding and hydrolytic cleavage |
| Authors: | Reddy, Pulimamidi Rabindra
Shilpa, Addla |
| Keywords: | Bioinorganic chemistry
DNA cleavage
Copper
Hydrolysis
Metalloenzymes |
| Issue Date: | Aug-2010 |
| Publisher: | CSIR |
| Citation: | Interaction of DNA with small molecules: Role of copper histidyl peptide complexes in DNA binding and hydrolytic cleavage |
| IPC Code: | Int. Cl.9 CO7F1/08 |
| Abstract: | Deoxyribonucleic acid is the site of storage
and retrieval of genetic information through interaction with proteins and
other small molecules. Hydrolysis of the phosphodiester bond of DNA is of
critical importance at several stages in a cell cycle. Thus, the development of
metal complexes that cleave nucleic acids hydrolytically at physiological
conditions is of great interest in the field of artificial metallonucleases.
Among transition metals, Cu(II) complexes have been extensively studied in
promoting hydrolysis of DNA. Histidine is a biologically important ligand for
Cu(II) binding in many biological systems. Since imidazole is an efficient
catalyst for ester hydrolysis at neutral pH
and histidine residues are often involved in neutral hydrolytic metalloenzyme
active centres and have the potential to bind to DNA, an attempt is made in
this review to highlight the importance of DNA binding and cleavage and the role of a few copper histidyl peptide complexes in DNA binding and
hydrolytic cleavage. |
| Page(s): | 1003-1015 |
| Source: | IJC-A Vol.49A(08) [August 2010]
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