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IJMS Vol.39(2) [June 2010] >

Title: Antifouling sesquiterpene from the Indian soft coral, Sinularia kavarattiensis Alderslade and Prita
Authors: Mol, V P Limna
Raveendran, T V
Parameswaran, P S
Kunnath, R J
Sathyan, N
Keywords: Soft coral
Sinularia kavarattiensis
Furoic acid
Balanus amphitrite
Issue Date: Jun-2010
Publisher: CSIR
Abstract: A sesquiterpene, (l'E,5'E)-2-(2',6'-dimethylocta-l',5',7'-trienyl)-4-furoic acid [1], was isolated for the first time from the soft coral Sinularia kavarattiensis Alderslade & Prita collected from Gulf of Mannar (Tamil Nadu, India). This compound exhibited considerable larval settlement inhibition properties against the cosmopolitan biofouler, Balanus amphitrite. The observed mean EC50 value of 11.21 µg/ml is well within the biological potency cut off set for natural product antifoulants (NPA’s). The low EC50 value and favourable therapeutic ratio (5.16) coupled with its known synthetic routes enhances the potential of 1 as a promising NPA.
Page(s): 270-273
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Source:IJMS Vol.39(2) [June 2010]

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