NISCAIR Online Periodicals Repository Collection: IJC-B Vol.49B(07) [July 2010]

Microwave assisted transformation of benzimidazolyl chalcones into N¹-substituted pyrazolines and evaluation of their antimicrobial activities

Mon, 28 Jun 2010 22:58:59 GMT

Title: Microwave assisted transformation of benzimidazolyl chalcones into N¹-substituted pyrazolines and evaluation of their antimicrobial activities

Authors: Rajora, Jayanti; Yadav, Janardan; Kumar, Ravindra; Srivastava, Yogendra K

Abstract: 1-Benzimidazolyl-3-aryl-prop-2-ene-1-ones 2 have been transformed into N¹-substituted pyrazoline derivatives by the interaction with phenyl hydrazine, thiosemicarbazide and hydrazine hydrate in the presence of formic acid under solvent free microwave induced protocol. The structure of newly synthesized compounds have been confirmed on the basis of their elemental analysis and spectral data. Newly synthesized compounds have been evaluated for their antimicrobial activity in vitro against E. coli, K. pneumonae, P. aeruginosa and B. subtilis using paper disc method. Some of the compounds have shown significant activity against the pathogens.

Page(s): 989-993

Designing hydroxy-functionalized chiral salen ligand and its use in the synthesis of dioxadiazasilamacroheterocycles

Mon, 28 Jun 2010 22:58:59 GMT

Title: Designing hydroxy-functionalized chiral salen ligand and its use in the synthesis of dioxadiazasilamacroheterocycles

Authors: Singh, M S; Singh, Pratibha; Gupta, Ashutosh

Abstract: Synthesis of dioxadiazasilamacroheterocycles is described. The key step involves the initial synthesis of symmetrical hydroxyl-functionalized chiral salen ligand, N,N′-bis(2-hydroxyacetophenonylidene)-1,2-diaminocyclohexane followed by sequential deprotonation with NaH to form dianion intermediate in situ, which reacts with diorganodichlorosilanes to furnish desired heterocycles. The products have been characterized by satisfactory elemental analyses and spectral (IR, ¹H, ¹³C, ²⁹Si NMR and mass) studies.

Page(s): 985-988

A facile Ph₃P/CO₂ mediated, one-pot synthesis of 2-oxazolidinones from 1,2-azido alcohols via phosphazene and isocyanate intermediates

Mon, 28 Jun 2010 22:58:59 GMT

Title: A facile Ph₃P/CO₂ mediated, one-pot synthesis of 2-oxazolidinones from 1,2-azido alcohols via phosphazene and isocyanate intermediates

Authors: Madhusudhan, G; Reddy, M Srinivasa; Reddy, Y Narayana; Vijayalakshmi, V; Suribabu, M; Balraju, V

Abstract: A facile, efficient and convenient method has been developed for the one-pot synthesis of 2-oxazolidinones from the corresponding 1,2-azido alcohols via phosphazene and isocyanate intermediates in presence of Ph₃P/CO₂ in toluene.

Page(s): 978-984

Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol- 4-yl)-6-aryl-pyridin-2-yl] and 4-methyl- 3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins

Mon, 28 Jun 2010 22:58:59 GMT

Title: Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol- 4-yl)-6-aryl-pyridin-2-yl] and 4-methyl- 3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins

Authors: Brahmbhatt, D I; Kaneria, Ankit R; Patel, Anil K; Patel, Niraj H

Abstract: Various 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 4a-l and 4-methyl-3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 5a-f have been synthesized by reacting 3-coumarinoylmethyl pyridinium bromides 1a,b and 4-methyl-3-phenyl-6-coumarinoylmethyl pyridinium bromide 2 with pyrazolyl chalcones 3a-f respectively under Krohnke’s reaction conditions. All the synthesized compounds 4a-l and 5a-f have been screened for their antibacterial activity against Escherichia coli (Gram -ve bacteria), Bacillus subtillis (Gram +ve bacteria) and antifungal activity against Candida albican (Fungi).

Page(s): 971-977

NISCAIR Online Periodicals Repository Collection: IJC-B Vol.49B(07) [July 2010]

Microwave assisted transformation of benzimidazolyl chalcones into N1-substituted pyrazolines and evaluation of their antimicrobial activities

Designing hydroxy-functionalized chiral salen ligand and its use in the synthesis of dioxadiazasilamacroheterocycles

A facile Ph3P/CO2 mediated, one-pot synthesis of 2-oxazolidinones from 1,2-azido alcohols via phosphazene and isocyanate intermediates

Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol- 4-yl)-6-aryl-pyridin-2-yl] and 4-methyl- 3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins

Microwave assisted transformation of benzimidazolyl chalcones into N¹-substituted pyrazolines and evaluation of their antimicrobial activities

A facile Ph₃P/CO₂ mediated, one-pot synthesis of 2-oxazolidinones from 1,2-azido alcohols via phosphazene and isocyanate intermediates