http://nopr.niscair.res.in/handle/123456789/8773 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/9101 Title: 1,3-Dipolar cycloaddition reactions: Synthesis and antimicrobial activity of novel 1-triazolylethylindole and 1-triazolylethylbenz[g]indole derivatives <br/> <br/>Authors: Bhovi, Manjunath G; Gadaginamath, Guru S <br/> <br/>Abstract: Indole azide <b style="">4</b> and benz[g]indole azide <b style="">12</b> are reacted separately with dimethyl acetylenedicarboxylate to secure the desired 1-[4,5-dimethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole <b style="">5</b> and 1-[4,5-di­methoxy­carbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylbenz[g]indole <b style="">13,</b> respectively. The reac­tion of indole azide <b style="">4</b> and benz[g]indole azide <b style="">12</b> with ethyl propiolate has been found to be regiospecific and produce only the 1-[4-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole <b style="">6</b> and 1-[4-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylbenz[g]indole <b style="">14,</b> respectively. Indole azide <b style="">4</b> is also reacted with ethyl phenylpropolate to secure two isomeric products 1-[4-ethoxycarbonyl-5-phenyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole <b style="">8</b> and 1-[4-phenyl-5-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole <b style="">9</b>. All these newly synthesised compounds are screened for their antimicrobial activities. <br/> <br/>Page(s): 1068-1073 Thu, 28 Apr 2005 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/9100 Title: Synthesis and antimicrobial activity of 10<i style="">N</i>-{[(Aryl)-amino]-methyl}-3-methoxy-10,10<i style=""><img src='/image/spc_char/alpha.gif' border=0></i> – dihydro -4<i style=""><img src='/image/spc_char/alpha.gif' border=0> -H</i>-phenothiazine-9-carboxylic acid <br/> <br/>Authors: Radadiya, V R; Purohit, D M; Patolia, V N <br/> <br/>Abstract: The titled compounds <b style="">3a-r</b> have been synthesized by the reaction of 3-methoxy-9-carboxy phenothiazine, formaldehyde and arylamine in the presence of hydrochloric acid (Mannich reaction). The biological activity of these compounds have been determined againsts various Gram +ve, Gram -ve bacteria and fungi. The constitution of the products are supported by IR, PMR and elemental analysis. <br/> <br/>Page(s): 1112-1114 Thu, 28 Apr 2005 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/9099 Title: Cyclodehydration reaction in water medium leads to library/multigram synthesis of 1,5-diarylpyrazoles <br/> <br/>Authors: Singh, Sunil K; Saibaba, V; Rao, Y Koteswar <br/> <br/>Abstract: The cyclodehydration reaction leading to 1,5-diarylpyrazoles in water medium has been observed for the first time. The method has been used in generating library of compounds for drug discovery program under microwave condition and tried for a multigram synthesis of celecoxib, a premier COX-2 inhibitor, under normal laboratory condition. <br/> <br/>Page(s): 1115-1118 Thu, 28 Apr 2005 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/9098 Title: Determining ring-F configuration in spirostane-type steroidal sapogenins by ¹H NMR <br/> <br/>Authors: Agrawal, Pawan K <br/> <br/>Abstract: A comparison of ¹H NMR chemical shifts for 25<i>R</i> and 25<i>S</i> spirostane-type steroidal sapogenins and saponins suggest that orientation of 27-Me group has quite a different influence on chemical shifts of the methylene protons occupying <img src='/image/spc_char/beta.gif' border=0>-and <img src='/image/spc_char/gamma.gif' border=0>-positions, thus providing valuable information about the establishment 25<i>R</i>-and 25<i>S</i>-stereochemistry in these compounds. <br/> <br/>Page(s): 1092-1094 Thu, 28 Apr 2005 22:58:59 GMT