http://nopr.niscair.res.in/handle/123456789/6315 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/6503 Title: Secretory factors of human neuroblastoma (IMR-32) and human glioblastoma (U87MG) cell lines induce neurite outgrowths in PC12 cells <br/> <br/>Authors: Satpute, Ravindra M; Kashyap, Rajpal S; Kainthla, Rani Poonam; Purohit, Hemant J; Taori, Girdhar M; Daginawala, Hatim F <br/> <br/>Abstract: Neurite outgrowth is essential for the communication of the nervous system. The rat Pheochromocytoma (PC12) cells are commonly used in the neuronal cell study. It is well known that exogenous stimuli such as Nerve Growth Factor (NGF) induce neurite outgrowth. In the present study it has been investigated whether or not the conditioned medium from human neuroblastoma cell line (IMR-32) and human glioblastoma cell line (U87MG) may augment neurite outgrowth in PC12 cells. PC12 were cultured with and without conditioned media of IMR-32 and U87MG. The result showed that both the conditioned media induce neurite outgrowth within 48 hr and stops further proliferation of PC12 cells. However no outgrowth was noted in PC12 cells incubated without conditioned medium. In conclusion, it is shown that both the conditioned media (IMR-32 and U87MG) have the potential to induce the neurite outgrowth in the PC12 cells. <br/> <br/>Page(s): 367-370 Fri, 28 Apr 2006 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/6502 Title: Nanotechnology based drug delivery system(s) for the management of tuberculosis <br/> <br/>Authors: Pandey, Rajesh; Khuller, G K <br/> <br/>Abstract: The era of nanotechnology has allowed new research strategies to flourish in the field of drug delivery. Nanoparticle-based drug delivery systems are suitable for targeting chronic intracellular infections such as tuberculosis. Polymeric nanoparticles employing poly lactide-co-glycolide have shown promise as far as intermittent chemotherapy in experimental tuberculosis is concerned. It has distinct advantages over the more traditional drug carriers, i.e. liposomes and microparticles. Although the experience with natural carriers, e.g. solid lipid nanoparticles and alginate nanoparticles is in its infancy, future research may rely heavily on these carrier systems. Given the options for oral as well as parenteral therapy, the very nature of the disease and its complex treatment urges one to emphasize on the oral route for controlled drug delivery. Pending the discovery of more potent antitubercular drugs, nanotechnology-based intermittent chemotherapy provides a novel and sound platform for an onslaught against tuberculosis. <br/> <br/>Page(s): 357-366 Fri, 28 Apr 2006 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/6501 Title: Analgesic activity of leaf extracts of <i style="">Culcasia scandens</i> P. Beauv <br/> <br/>Authors: Okoli, C O; Akah, P A; Egbuniwe, O N <br/> <br/>Abstract: Analgesic activity of methanol leaf extract of <i style="">C. scandens</i> obtained by column chromatography and its graded solvent fractions, was evaluated in mice using acetic acid-induced abdominal writhing and formalin-induced paw licking. The extract and fractions significantly inhibited abdominal writhing and two phases of formalin-induced paw licking in mice, indicating that antinociceptive activity may involve inhibition of pain by peripheral and central mechanisms. <br/> <br/>Page(s): 422-424 Fri, 28 Apr 2006 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/6500 Title: Modification of biochemical parameters of gentamicin nephrotoxicity by Coenzyme Q10 and green tea in rats <br/> <br/>Authors: Upaganlawar, Aman; Farswan, Mamta; Rathod, Shivkumar; Balaraman, R <br/> <br/>Abstract: The present study was designed to investigate the possible potential protective role of coenzymeQ10 (CoQ10; 10mg/kg/day, ip) and/or green tea (GT; 25mg/kg/day, po) against gentamicin (GM) nephrotoxicity. Marked increase in the level of serum urea, creatinine and lipid peroxidation (LPO) content was found after administration of gentamicin (80mg/kg/day, ip) for eight days along with significant decrease in the antioxidant enzymes, superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT) as well as brush border enzymes (Na⁺/K⁺ATPase, Mg⁺²ATPase and Ca²⁺ ATPase).Treatment with CoQ10 or green tea alone with GM showed significant decrease in serum urea, creatinine and tissue LPO content and significant increase in antioxidant and membrane bound enzymes. Combined treatment with CoQ10 and green tea was more effective in mitigating adverse effect of GM nephrotoxicity. The present work indicated that CoQ10 and green tea due to their antioxidant activity modified the biochemical changes occurred during gentamicin nephrotoxicity and thus had a potential protective effect. <br/> <br/>Page(s): 416-418 Fri, 28 Apr 2006 22:58:59 GMT