NISCAIR Online Periodicals Repository Collection: JSIR Vol.63(10) [October 2004]

Three new methods for the assay of albendazole using N-chlorosuccinimide

Tue, 28 Sep 2004 22:58:59 GMT

Title: Three new methods for the assay of albendazole using N-chlorosuccinimide

Authors: Basavaiah, K; Nagegowda, P

Abstract: Two titrimetric and one spectrophotometric methods are described for the determination of albendazole in pure form and in formulations. In direct titrimetric procedure (Method A), the drug is titrated directly with N-chlorosuccinimide solution in hydrochloric acid medium using indigo carmine as indicator. In back titrimetry (Method B) the drug is treated with a measured excess of the oxidant in acetic acid medium followed by the determination of the residual oxidant iodometrically. Spectrophotometry (Method C), involves the addition of a known excess of N-chlorosuccinimide to albendazole in hydrochloric acid medium followed by the determination of surplus oxidant by oxidation and complexation reactions involving iron (II) and thiocyanate. The absorbance of the resulting orange-red colour was measured at 480 nm and related to albendazole concentration. Titrimetric assays are based on a 1:2 reaction stiochiometry between albendazole and N-chlorosuccinimide. Direct titrimetry is applicable over 2-13 mg range, and 4-14 mg of albendazole could be determined by back titration method. In spectrophotometry the regression analysis of Beer’s law plot showed a good correlation between 0.62-10.0 g/mLalbendazole with a correlation coefficient of -0.9964. The molar absorptivity and Sandell sensitivity were 4.14 x 10⁴ L/moL/cm and 18. 82 ng/cm², respectively. The limits of detection and quantification, respectively, were 0.61 and 2.02 g/mL. The proposed methods were applied successfully for the determination of albendazole in pharmaceutical formulations with mean recoveries of 97.36 to 102.36 per cent. The excipients present in formulations did not interfere. The accuracy and reliability of the methods were further established by parallel determination by the reference method, and by recovery studies.

Page(s): 835-841

Development of portable metal oxide gas sensor for the detection of foul odour

Tue, 28 Sep 2004 22:58:59 GMT

Title: Development of portable metal oxide gas sensor for the detection of foul odour

Authors: Ghanshyam, C; Mishra, Sunita; Sharma, A K; Ram, N; Singh, Satinder; Bajpai, R P; Bedi, R K

Abstract: Halitosis or oral malodour originates with the anaerobic bacterial degradation of sulphur containing amino acids within the oral cavity resulting in the emission of hydrogen sulphide (H₂S), methyl mercaptan (CH₃SH) and dimethyl sulphide (CH₃SCH₃), collectively known as volatile sulphur compounds (VSCs). The sensing of VSCs is needed for dentistry as well as for auto-ventilation applications. This paper discusses the design and development of the portable and low cost metal oxide based gas sensor for the foul odour applications. The substrate design, the sensor parameters and the proposed in-house works are described.

Page(s): 842-845

Studies on polysulphide pulping of Populus deltoides

Tue, 28 Sep 2004 22:58:59 GMT

Title: Studies on polysulphide pulping of Populus deltoides

Authors: Rao, Suhail Akhtar; Upadhyaya, J S

Abstract: Addition of polysulphide (PS) during the pulping is investigated in the laboratory. Polysulphide was found to be advantageous to extend the cooking. The present study deals with polysulphide pulping of Populus deltoids Marsh The benefits gained were in terms of increased pulp yield without considerably affecting the quality of the pulp. The tear and burst values of the PS pulps were found to be slightly lower, while the tensile index values were found to be comparable with that of kraft pulp. The results demonstrate the better utilization of fibrous raw material for paper-making in terms of increased pulp yield and better physical and other strength properties of paper.

Page(s): 820-825

Studies on effect of titanate coupling agents on the mechanical properties of clay filled chloroprene rubber

Tue, 28 Sep 2004 22:58:59 GMT

Title: Studies on effect of titanate coupling agents on the mechanical properties of clay filled chloroprene rubber

Authors: Alkadasi, Nabil A N; Sarwade, Bhimrao D; Hundiwale, D G; Kapadi, U R

Abstract: Clays belong to economic class of fillers, which are used extensively in rubbers and plastics. Being non-reinforcing in nature there are limitations for its use. If the properties of filler are modified it will get higher value as a filler. To achieve this modification of surface properties use of coupling agents is one of the avenues. In the present work, effect of treatment of titanate coupling agent on clay has been studied with chloroprene as a matrix. Composites were made with varying proportion of untreated and treated clay. A two-roll mill was used for dispersing the filler in the rubber and compression moulding technique was used to cure the compound in sheet form. Tensile properties were measured on a computerized UTM, using ASTM procedure. Comparison of properties of composites filled with treated and untreated clay established that treatment of clay imparts better reinforcing properties. The properties under consideration were tensile strength, modulus at 100 and 400 per cent, Young’s modulus, hardness, etc. Tensile strength was improved by 166 per cent, while modulus at 400 per cent was improved by 167 per cent. Similarly, Young’s modulus also was improved by 155 per cent

Page(s): 830-834