http://nopr.niscair.res.in/handle/123456789/5164 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/5741 Title: Nanotechnology and pharmaceutical inhalation aerosols <br/> <br/>Authors: Patel, A R; Vavia, P R <br/> <br/>Abstract: Pharmaceutical inhalation aerosols have been playing a crucial role in the health and well being of millions of people throughout the world for many years. The technology’s continual advancement, the ease of use and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years. But administration of drugs by the pulmonary route is technically challenging because oral deposition can be high, and variations in inhalation technique can affect the quantity of drug delivered to the lungs. Recent advances in nanotechnology, particularly drug delivery field have encouraged formulation scientists to expand their reach in solving tricky problems related to drug delivery. Moreover, application of nanotechnology to aerosol science has opened up a new category of pharmaceutical aerosols (collectively known as nanoenabled-aerosols) with added advantages and effectiveness. In this review, some of the latest approaches of nano-enabled aerosol drug delivery system (including nano-suspension, trojan particles, bioadhesive nanoparticles and smart particle aerosols) that can be employed successfully to overcome problems of conventional aerosol systems have been introduced. <br/> <br/>Page(s): 166-174 Mon, 29 Jan 2007 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/5690 Title: Protective effect of hesperidin on nicotine induced toxicity in rats <br/> <br/>Authors: Balakrishnan, Annida; Menon, Venugopal P <br/> <br/>Abstract: Nicotine administration (2.5 mg/kg of body weight, sc, 5 days a week for 22 weeks) enhanced lipid peroxidative indices (thiobarbituric acid reactive substances and hydroperoxides) accompanied by a significant increase in the marker enzymes alanine transaminase, aspartate transaminase, alkaline phosphatase and lactate dehydrogenase and elevated levels of cholesterol, triglycerides, phospholipids and free fatty acids in Wistar rats. There was a significant protection by hesperidin administration at different doses (25, 50, 75, 100 and 150 mg/kg body weight) in nicotine-treated rats. However, the effect of hesperidin was more significant at 25mg/kg dose. The results suggest that hesperidin exerts the protective effects by modulating the extent of lipid peroxidation. The results are supported by histopathological observations of lung, liver and kidney. <br/> <br/>Page(s): 194-202 Mon, 29 Jan 2007 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/5689 Title: Cloning of medicinal plants through tissue culture —A review <br/> <br/>Authors: Chaturvedi, H C; Jain, Madhu; Kidwai, N R <br/> <br/>Abstract: In order to have standardized formulations, the chemical constituents from plants and their parts are required to be uniform both qualitatively and quantitatively. Furthermore, an ever increasing demand of uniform medicinal plants based medicines warrants their mass cloning through plant tissue culture strategy. A good number of medicinal plants have been reported to regenerate <i style="">in vitro </i>from their various parts, but a critical evaluation of such reports reveals that only a few complete medicinal plants have been regenerated and still fewer have actually been grown in soil, while their micropropagation on a mass scale has rarely been achieved, particularly in those medicinal plants where conventional propagation is inadequate, like, the mass clonal propagation of <i style="">Dioscorea floribunda </i>leading to its successful field trials. Such facts make it imperative to document the factual position of micropropagation of medicinal plants bringing out the advancements made along with the short falls, in this important area. The present review deals with the futuristic view on the said subject restricted to higher plants. <br/> <br/>Page(s): 937-948 Mon, 29 Oct 2007 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/5688 Title: Neuroprotective effects of vitamin E in cold induced cerebral injury in guinea pigs <br/> <br/>Authors: Badhe, Prerna; Thorat, Jayant; Diyora, Batuk D; Mamidanna, Ravikrishna; Sayal, Parag; Badhe, Suvarna; Sharma, Alok K <br/> <br/>Abstract: Significant reduction in hemorrhage (10 v/s 13), necrosis (2 v/s 4), cavitations (7 v/s 13), neuronal degeneration, perivascular and parenchymal inflammatory infiltrate (7 v/s 11) were observed in Vitamin E treated cold induced head injury in guinea pigs, evaluated post injury using the modified Benderson’s scale. The results suggest that Vitamin E is highly effective in promoting clinical and histopathological recovery in cold induced head injury in guinea pigs. <br/> <br/>Page(s): 180-184 Mon, 29 Jan 2007 22:58:59 GMT