http://nopr.niscair.res.in/handle/123456789/321 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/813 Title: A simple two-step synthesis of avenanthramides, constituents of oats (Avena sativa L) <br/> <br/>Authors: Kamat, Shrivallabh P; Parab, Sulaksha J <br/> <br/>Abstract: A simple two-step general procedure has been developed to prepare naturally occurring and synthetic avenanthramides, constituents of oats (Avena sativa L). Reaction of anthranilic acid 1 with Meldrum’s acid 2 gives half amide of malonic acid 3 which on condensation with different benzaldehyde derivatives 4a-m gives avenanthramides 5a-m of which 5a-d are natural, 5e-g are their methyl ethers and 5h-m are synthetic. <br/> <br/>Page(s): 2074-2078 Wed, 28 Nov 2007 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/812 Title: Efficient synthesis of 6-aryl-12H-pyrido[2',3':4,5] pyrimido [1,2-a][1,8] naphthyridin-12-ones under microwave irradiation <br/> <br/>Authors: Mogilaiah, K; Anitha, E; Vidya, K; Reddy, N Vasudeva <br/> <br/>Abstract: A straightforward and highly efficient procedure has been described for the synthesis of 6-aryl-12H-pyrido[2',3':4,5]pyrimido [1,2-⍺][1,8]naphthyridin-12-ones 3 by the reaction of 3-aryl-2-chloro-1,8-naphthyridines 1 with 2-aminonicotinic acid 2 in glacial acetic acid under microwave irradiation. The products are obtained in very good yields and in a state of high purity. The structural assignments of compounds 3 were based on their elemental analyses and spectral (IR and ¹H NMR) data. <br/> <br/>Page(s): 2071-2073 Wed, 28 Nov 2007 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/810 Title: Synthesis of substituted steroidal thiadiazole, triazole and oxidotriazole <br/> <br/>Authors: Shamsuzzaman; Siddiqui, Tabassum; Alam, Mohd. Gulfam <br/> <br/>Abstract: Ethyl-5-cholesten-3β-O-acetate 2 and its thiosemicarbazide 3 have been synthesized by the reaction of 3β-hydroxycholest-5-ene 1 with ethyl chloroacetate and 2 with thiosemicarbazide in 1,4 dioxane, respectively. The thiosemicarbazide 3 on chemoselective heterocyclization with conc. H₂SO₄, conc. NaOH and iodine in the presence of alkali separately afforded 3β-[5'-amino-1',2',4'-thiadiazole-3'-methoxy]-cholest-5-ene 4,3β-[5'-mercapto-1',2',4'-triazole-3'-methoxy]-cholest-5-ene 5 and 3β-[5'-mercapto-3',5'-oxido-1',2',4'-triazolo-3'-methoxy]-5⍺-cholestane 6, respectively. The structures of these compounds have been established on the basis of elemental, analytical and spectral data. <br/> <br/>Page(s): 2068-2070 Wed, 28 Nov 2007 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/807 Title: Synthesis and anti-inflammatory activity of fluorinated chalcone derivatives <br/> <br/>Authors: Jadhav, Dhanaji H; Ramaa, C S <br/> <br/>Abstract: A series of twelve 2',4'-difluorinated chalcones have been synthesized by Claisen-Schmidt condensation of 2',4'-difluoroacetophenone with appropriately substituted benzaldehydes. These compounds have then been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat paw oedema model. Compounds 1, 7, 10 and 11 have activity comparable to indomethacin at 20 mg kg⁻¹ by oral route. <br/> <br/>Page(s): 2064-2067 Wed, 28 Nov 2007 22:58:59 GMT