NISCAIR Online Periodicals Repository Collection: IJCT Vol.15(5) [September 2008]

Electrochemical detection of heparin based on its interaction with acridine orange

Fri, 29 Aug 2008 22:58:59 GMT

Title: Electrochemical detection of heparin based on its interaction with acridine orange

Authors: Niu, Xueliang; Sun, Wei; Zhao, Na; Jiao, Kui

Abstract: The interaction of acridine orange (AO) with heparin was studied by voltammetric method. In Britton-Robinson (B-R) buffer solution (pH 2.3), AO showed a sensitive linear sweep voltammetric reductive peak at -0.94 V (vs. SCE). The addition of heparin into the AO solution caused a decrease in the reductive peak current without any change in the peak potential. The results indicated that a reaction occurred between the positively charged AO and the negatively charged heparin, which led to the decrease of the free AO concentration and subsequent decrease of the reductive peak current of AO. Under the optimal conditions, the decrease of reductive peak current of AO was proportional to heparin concentration in the range of 0.8-6.0 mg L⁻¹ and the data reductive peak current were correlated as ∆ip″(nA)=807.58 C (mg L⁻¹)-542.51 (n=10, correlation coefficient ϒ=0.995) and the detection limit was calculated as 0.13 mg L⁻¹ (3 S₀/S). The new method was successfully applied to the determination of heparin content in heparin sodium injection samples with satisfactory results and good recovery. The interaction of the reactants was also confirmed by UV-Vis absorption spectrophotometric experiments.

Page(s): 476-482

Electrochemical behaviour of famotidine in pharmaceutical formulation at composite polymer membrane electrode

Fri, 29 Aug 2008 22:58:59 GMT

Title: Electrochemical behaviour of famotidine in pharmaceutical formulation at composite polymer membrane electrode

Authors: Tiwari, D C; Jain, Rajeev; Sahu, Gaurav

Abstract: Electrochemical behaviour of famotidine has been studied at composite polymer membrane working electrode. Cyclic voltammetric method has been developed for the determination of drug in pharmaceutical formulation. A well-defined anodic peak was observed for famotidine in the entire pH range. The current increases steadily with scan rate and concentration. This composite film showed good catalytic behaviour, which includes a good current response. The result is compared with the glassy carbon electrode and it was found that the current with composite polymer electrode is of the order of 18.60 mA whereas with glassy carbon electrode it was around 565.00 μA.

Page(s): 472-475

Investigation of acid oil as a source of biodiesel

Fri, 29 Aug 2008 22:58:59 GMT

Title: Investigation of acid oil as a source of biodiesel

Authors: Kulkarni, B M; Pujar, B G; Shanmukhappa, S

Abstract: Acid oil which is a byproduct of vegetable oil industry has been investigated for its suitability as a source of biodiesel, as it is economic and readily available in considerable quantities at most of vegetable oil refinery sites. The biodiesel from acid oil is produced by a new type of “ED3R” esterification process developed at the Institute. Fuel properties of biodiesel thus produced are compared with standard biodiesel and diesel fuel. Blends of biodiesel and diesel fuel are prepared. Fuel property variations of biodiesel blends produced are reported.

Page(s): 467-471

Methyl orange as corrosion inhibitor for carbon steel in well water

Thu, 22 Jan 2009 07:30:30 GMT

Title: Methyl orange as corrosion inhibitor for carbon steel in well water

Authors: Sathiyabama, J; Rajendran, Susai; Selvi, J Arockia; Amalraj, A John

Abstract: The corrosion inhibition efficiency of methyl orange in controlling corrosion of carbon steel immersed in well water has been evaluated by weight loss method both in absence and presence of zinc ion. A synergistic effect exists between methyl orange (MO) and Zn²⁺. The inhibition efficiency (IE) of the MO – Zn²⁺ system decreases with increase in immersion period. Polarization study suggests that the MO-Zn²⁺ system functions as a mixed inhibitor system. FTIR spectra indicate that the protective film consists of Fe²⁺ - MO complex and Zn(OH)₂.

Page(s): 462-466