http://nopr.niscair.res.in/handle/123456789/2699 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/2756 Title: Synthesis of dibenzo-18-crown-6 ether containing pyrimidine derivatives <br/> <br/>Authors: Deshmukh, M B; Alasundkar, K N; Salunkhe, S M; Salunkhe, D K; Sankpal, S A; Patil, D R; Anbhule, P V <br/> <br/>Abstract: The strategy employed for the synthesis of new macromolecules containing pyrimidine moiety involved acetylation of dibenzo-18-crown-6 (1) to yield 4,4'-diacetyl derivative of dibenzo-18-crown-6 (2) which was further reacted with different aldehydes to give corresponding chalcone 3. Reaction of chalcones 4 with guanidine hydrochloride gives target molecule. The structures of synthesized compounds have been characterized on the basis of spectroscopic data. <br/> <br/>Page(s): 1915-1917 Fri, 28 Nov 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/2755 Title: An investigation leading to preparation of tetrahydro-quinazoline derivatives involving ureidoalkylation and ⍺-amidoalkylation reactions <br/> <br/>Authors: Pandey, V K; Mukesh; Kumar, Anilesh; Trivedi, Noopur <br/> <br/>Abstract: Reaction of an aldehyde with excess equivalent of urea in ethanol affords alkylideno/arylideno-bis-ureas 1 which on condensation with p-aminophenol in acidic medium cyclised to 4-aralkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 2. Reaction of 2 with arylamidoalcohols in concentrated H2SO4 results in 4-arylkyl-7-arylamido/imidoalkyl-6-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazolines 3. Compounds 3 have been evaluated for their effect on central nervous system (CNS) and cardiovascular system (CVS). <br/> <br/>Page(s): 1910-1914 Fri, 28 Nov 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/2754 Title: Synthesis of some novel ethoxyphthalimide derivatives of pyrazolo[3,4-c]pyrazoles <br/> <br/>Authors: Sharma, Chirag; Thadhaney, Bhawana; Pemawat, Gangotri; Talesara, G L <br/> <br/>Abstract: The synthesis of 5-methyl-4-substituted benzylidene-2,4-dihydro-3H-pyrazol-3-one 3a-d is achieved by the condensation reaction of 5-methyl-2,4-dihydro-3H-pyrazol-3-one 1 with 4-substituted benzaldehydes 2a-d. Compound 1 is prepared by the cyclization reaction between ethylacetoacetate and hydrazine hydrate in absolute alcohol. Compounds 3a-d are converted into corresponding ethoxyphthalimide derivatives 5a-d by treatment with phthalimidoxyethyl bromide 4. 1-N-Ethoxyphthlimido-3-methyl-4-(4-substituted benzylidene)pyrazol-5-ones 5a-d are reacted with thiosemicarbazide/NaOH and isoniazid/AcONa/AcOH separately to yield 6-N-ethoxyphthalimido-4-methyl-3-(4-substituted phenyl)-2-thiocarbamoyl-3,3a-dihydro pyrazolo[3,4-c]pyrazoles 6a-d and 6-N-ethoxyphthalimido-2-isonicotinoyl-4-methyl-3-(4-substituted phenyl)-3,3a-dihydro pyrazolo[3,4-c]pyrazoles 7a-d respectively. Structures of the synthesized compounds have been elucidated by means of IR, 1H NMR and mass spectral data. <br/> <br/>Page(s): 1892-1897 Fri, 28 Nov 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/2753 Title: Cycloaddition of 6-hydroxy-2,6-dimethylcyclohexa-2,4-dienone: A stereoselective entry into functionalized bicyclo[2.2.2]octanes and a novel 1,2-migration of methyl group <br/> <br/>Authors: Singh, Vishwakarma; Chandra, Girish; Mobin, Shaikh M <br/> <br/>Abstract: Cycloaddition of 6-hydroxy-2,6-dimethylcyclohexa-2,4-dienones with ethyl vinyl ether, butyl vinyl ether, vinyl acetate and vinyl phenyl sulphone leading to a stereoselective entry into bicyclo[2.2.2]octanes having quaternary methyl group is reported. A novel thermal 1,2-methyl migration has also been described. <br/> <br/>Page(s): 1886-1891 Fri, 28 Nov 2008 22:58:59 GMT