http://nopr.niscair.res.in/handle/123456789/1900 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/1935 Title: Alterations in immunoglobulins and cytokine levels in blood of malathion poisoning cases <br/> <br/>Authors: Seth, Vandana; Banerjee, B D; Ahmed, Rafat S; Bhattacharya, A; Pasha, S T <br/> <br/>Abstract: The excessive exposure and use of malathion, an organophosphate pesticide, has lead to deleterious effects on human health. Chronic exposure to organophosphates has been shown to suppress immune system in experimental animals. Therefore, in this study, we have investigated the immunoglobulins (IgG, IgM, IgE and IgA) and cytokines (IL-2, IL-4, IFN-ϒ and TNF-α) levels in blood of malathion poisoning cases, admitted in Guru Teg Bahadur Hospital (University of Delhi), Dilshad Garden, Delhi, India. All the seriously ill patients of malathion poisoning showed significant levels of residue (503-702 mg/L). While no significant changes were found in Igs levels in blood of malathion poisoning cases, there was a significant increase in IL-2, IL-4 and TNF-α levels in blood of malathion poisoning cases, and significant decrease in IFN-ϒ level, as compared to normal subjects. This study demonstrated altered levels of cytokines and interleukins in serum in response to malathion exposure. <br/> <br/>Page(s): 209-211 Thu, 29 May 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/1934 Title: Hepatoprotective effect of vitamin C on sodium nitrite-induced lipid peroxidation in albino rats <br/> <br/>Authors: Krishnamoorthy, P; Sangeetha, M <br/> <br/>Abstract: The possible protective role of vitamin C on liver antioxidant enzymes of albino rats in sodium nitrite induced lipid peroxidation (LPO) was investigated. Sodium nitrite and vitamin C were administered orally through intragastric tube. Sodium nitrite (300 mg/kg body wt.) significantly increased the LPO and the activities of liver marker enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), acid phosphatase and lactate dehydrogenase (LDH), and decreased the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) level in LPO-induced rats; the remarkable changes in the enzyme activities was due to hepatotoxicity of nitrite. The vitamin C (300 mg/kg body wt.) significantly decreased the LPO level and the activities of liver enzymes and increased antioxidant enzymes activities, thus exerts ameliorating effect on sodium nitriteinduced lipid peroxidation. <br/> <br/>Page(s): 206-208 Thu, 29 May 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/1933 Title: QSAR study of lipid peroxidation-inhibition potential of some phenolic antioxidants <br/> <br/>Authors: Ray, Supratim; De, Kakali; Sengupta, Chandana; Roy, Kunal <br/> <br/>Abstract: QSAR models have been developed for lipid peroxidation (LPO)-inhibition potential of a series of phenolic compounds in phosphate-buffered and pre-emulsified linoleic acid systems using the descriptors such as topological indices, topological charge indices and quantum chemical descriptors. In both model systems, a considerably large number (131) of descriptors have been used. The subsequent variable selection is made using standard techniques like stepwise regression and multiple linear regression (MLR) with factor analysis (FA) as the data-preprocessing step for variable selection (FA-MLR). The best equation is obtained from FA-MLR (R² = 0.950, Q² = 0.914) for the first system, and from stepwise regression analysis (R² = 0.960, Q² = 0.949) for the second system. The results reveal that bond dissociation enthalpy (BDE) and maximal electrotopological positive variation (MAXDP) have negative contributions to the LPO-inhibition activity. The best equations satisfy the Fmax criteria suggested by Livingstone and Salt (2005). The derived equations may be helpful in designing novel phenolic antioxidants. <br/> <br/>Page(s): 198-205 Thu, 29 May 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/1932 Title: Porcine pancreas lipase catalyzed synthesis of lauryl laurate in organic solvent media: A kinetic study <br/> <br/>Authors: Gogoi, Sumbita; Pathak, M G; Dutta, A; Dutta, N N <br/> <br/>Abstract: The esterification of lauric acid with lauryl alcohol was studied using lipase from Porcine pancreas, with particular emphasis on the effect of the pertinent variables and kinetic aspects of the reaction. The reaction was studied in eight different solvents having hydrophobicity (the logarithm of octanol-water partition coefficient, log P) values ranging from 0.6 to 3.5 with constant water content in the reaction mixture and n-hexane was the most suitable solvent. The initial rates of the reaction were attempted to correlate with solvent properties and a significant good correlation was obtained with solvent hydrophobicity (log P) and water solubility (log Sw). The kinetics of the esterification reaction conformed to the so-called Ping-Pong Bi-Bi mechanism with alcohol inhibition. <br/> <br/>Page(s): 192-197 Thu, 29 May 2008 22:58:59 GMT