http://nopr.niscair.res.in/handle/123456789/1888 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/1924 Title: Alstonoside, a secoiridoid glucoside from Alstonia scholaris <br/> <br/>Authors: Thomas, P Steve; Kanaujia, Anil; Ghosh, Dipankar; Duggar, Rajeev; Katiyar, Chandra Kant <br/> <br/>Abstract: From the stems of Alstonia scholaris, a new secoiridoid glucoside, named alstonoside 1, together with two isoflavone apioglucosides, formononetin 7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside 2 and biochanin A 7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside 3 are isolated and their structures are elucidated on the basis of detailed 1D and 2D-NMR and mass spectral data. Alstonoside features the presence of a ring opened monocyclic iridoid glucoside with the presence of an O-benzoyl moiety. This study constitutes the first report of a new secoiridoid glucoside and two isoflavone apioglucosides from this plant. <br/> <br/>Page(s): 1298-1302 Tue, 29 Jul 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/1923 Title: Lipase catalyzed asymmetric synthesis of (R)-melonol <br/> <br/>Authors: Syam, Sujata; Rane, Monica D; Bhat, Sujata V <br/> <br/>Abstract: Synthesis of optically pure 2,6-dimethyl-5-hepten-1-ol (melonol) has been attempted using lipases. Among three different lipases tested, pig pancreatic lipase (PPL) is found to be suitable for transesterification of (±)-melonol to afford (R)-(+)-melonol with an enantiomeric excess of 94%. <br/> <br/>Page(s): 1308-1310 Tue, 29 Jul 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/1922 Title: Synthesis and biological evaluation of some new 4,5-dihydro-3-(2-aryl-indol-3-yl)-5- (4-chlorophenyl)-N¹-phenylpyrazoles <br/> <br/>Authors: Pathak, Vijai Nath; Gupta, Ragini; Gupta, Neetu <br/> <br/>Abstract: A facile and clean cyclization of indolylchalcone with phenyl hydrazine in glacial acetic acid occurs to afford 4,5-dihydro-3-(2-arylindol-3-yl)-5- (4-chlorophenyl)-N¹-phenylpyrazoles 5a-e in quantitative yield using 'Grindstone' technique. The results obtained indicate that, unlike classical heating, grinding method results in higher yields, shorter reaction time and cleaner reaction conditions. All the synthesized compounds have been characterized by their elemental analyses and spectral data (IR, ¹H NMR). Antibacterial and antifungal activity of all synthesized compounds have also been evaluated and some of them show promising results against E. coli, S. aureus, C. albicans and A. niger. <br/> <br/>Page(s): 1303-1307 Tue, 29 Jul 2008 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/1921 Title: Synthesis of some sulphonamide insect juvenile hormone - Part I <br/> <br/>Authors: Awasthi, Pamita; Mahajan, R K <br/> <br/>Abstract: Regular use of classical insecticides has drastically effected the environment and warm blooded animals. Therefore, there is an urgent need to look for a kind of chemicals which are very specific, targeted in their action and environment friendly. Since long, study on juvenile hormones is in progress to be a potential insecticide. Large no of compounds have been reported in literature with diverse structural features like amides, esters, hydroxamates, incorporated in the side arm which exhibit promising juvenile hormone activities and also decomposes when come in contact with environment. In this regard the synthesis of some of juvenile hormone analogues as a potential pesticide is reported. The synthesis of juvenile hormone analogues 4-29 containing sulphonamide features is presented. Preliminary biological screening of one representative; N-(1-methyl-oxo-2-piperidino-ethyl) benzene sulphonamide 24 reveals the positive juvenile hormone activity and chemosterilizing effect against potato tumor moth phthorimaea opercula. <br/> <br/>Page(s): 1291-1297 Tue, 29 Jul 2008 22:58:59 GMT