NISCAIR Online Periodicals Repository Collection: IJC-B Vol.51B(06) [June 2012]

Synthesis and antiulcer activity study of disubstituted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thioxo-3,4-dihydroquinazolin-1(2H)-yl) methyl)-1,4-dihydropyridine-3,5 dicarboxylate

Tue, 29 May 2012 22:58:59 GMT

Title: Synthesis and antiulcer activity study of disubstituted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thioxo-3,4-dihydroquinazolin-1(2H)-yl) methyl)-1,4-dihydropyridine-3,5 dicarboxylate

Authors: Subudhi, B B; Panda, S K; Ghosh, G; Panda, P K

Abstract: A 2-amino-N-(4-sulfamoyl phenyl) benzamide 1 has been prepared by reaction of anthranilic acid with sulfanilamide. Compound 1 with carbon disulphide furnish 4-(4-oxo-2-thioxo-1, 2-dihydroquinazolin-3(4H)-yl) benzene sulfonamide 2. The compound 2 on reaction with para formaldehyde and 1,4-dihydropyridine derivatives yields disubstituted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thioxo-3,4-dihydroquinazolin-1(2H)-yl) methyl)-1,4-dihydropyridine-3,5 dicarboxylate 3a-h. Antiulcer activities of compounds 3a-h have been evaluated by estimating volume of gastric juice, total acidity, free acidity and ulcer index. Conjunction of 1,4-dihydropyridines with sulfanilamide and quinazolinone results in compounds with antiulcer activity comparable to that of ranitidine. Compounds substituted with methoxy and nitro groups exhibit maximum enhancement in activity.

Page(s): 899-903

Photochemical synthesis of 9-methoxy-5-thiophenyl-12H-benzo[a] xanthene-12-one

Tue, 29 May 2012 22:58:59 GMT

Title: Photochemical synthesis of 9-methoxy-5-thiophenyl-12H-benzo[a] xanthene-12-one

Authors: Miya, Mohd Basheer; Rao, Y Jayaprakash; Krupadanam, G L David

Abstract: Photochemical oxidation of 7-methoxy-3-phenyl-2-[(E)-2-(thiophen-2-yl)ethenyl]-4H-chromen-4-one 4 in methanol containing iodine in the presence of air afforded 9-methoxy-5-thiophenyl-12H-benzo[a] xanthene 5. The structure of the photo products was confirmed by IR, UV-Vis, ¹H NMR and mass spectra. A suitable mechanism has been proposed.

Page(s): 895-898

Conventional and microwave-assisted synthesis of 1,5-diaryl-2-thiohydantoins

Tue, 29 May 2012 22:58:59 GMT

Title: Conventional and microwave-assisted synthesis of 1,5-diaryl-2-thiohydantoins

Authors: Baile, M B; Mahajan, S S

Abstract: A simple and efficient method for synthesis of new 1,5-diaryl-2-thiohydantoins using microwave radiation has been standardized. The compounds have been synthesized from phenyl¬acetic acid by esterification, bromination, amination and cyclization using conventional as well microwave irradiation methods.

Page(s): 891-894

Synthesis, characterization and microbial assay of new pyridoquinolone-3-carboxamides

Tue, 29 May 2012 22:58:59 GMT

Title: Synthesis, characterization and microbial assay of new pyridoquinolone-3-carboxamides

Authors: Patel, Navin B; Pathak, Kunal K; Patel, Jignesh N; Modi, Sandip H

Abstract: The ethyl pyrido[2,3-h]quinolone carboxamides 7-31 have been synthesized and their ability to inhibit Gram positive strains B. subtilis and S. aureus and Gram negative strains E. coli and P. aeruginosa have been tested. Only carboxamides with piperazine derivatives attached at C-3 position show good antibacterial potency compared to standard ciprofloxacin and gatifloxacin. Piperazine derivatives attached at C-3 position of N-ethyl pyrido quinolone increase the activity of their parent compound acid 6, whereas aryl urea attached at this position decrease the antibacterial activity.

Page(s): 880-890