NISCAIR Online Periodicals Repository Collection: IJC-B Vol.50B(06) [June 2011]

Synthesis of some N,N-diethoxyphthalimido-5-(substitutedphenyl)-3-methyl-1,3a,4,5-tetrahydropyrazolo[3,4-c] pyrazole-4-spiro-5-substituted-1H-indole-2-one

Sun, 29 May 2011 22:58:59 GMT

Title: Synthesis of some N,N-diethoxyphthalimido-5-(substitutedphenyl)-3-methyl-1,3a,4,5-tetrahydropyrazolo[3,4-c] pyrazole-4-spiro-5-substituted-1H-indole-2-one

Authors: Hussain, Nasir; Dangi, Rajaram; Sharma, Chirag Kumar; Talesara, Ganpat Lal

Abstract: 5-Methyl-2,4-dihydro-3H-pyrazol-3-one reacts with isatin 1a,b in ethanol to give a solid product. On addition of warm benzene, one part (benzene soluble) is 4a,b and another part (benzene insoluble) is 2a,b. Compounds 3,5-dimethyl-4,7-dihydro-1H-pyrazolo[4′,3′:5,6]pyrano[2,3c]pyrazole-4-spiro-5-substituted-1H-indole-2-one 2a,b on treatment with bromoethoxyphthalimide in DMF yield N,N,N-triethoxyphthalimido-3,5-dimethyl-4,7-dihydro-1H-pyrazolo [4′,3; 5,6]pyrano[2,3-c]pyrazole-4-spiro-5-substituted-1H-indole-2-one 3a,b. 3-(3-Methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1,3-dihydro-2H-indol-2-one 4a,b are converted to corresponding pyrazolopyrazole derivatives 5a-f by reaction with substituted phenylhydrazine. These are finally condensed with bromoethoxyphthalimide in DMF and pyridine as a base to give titled compounds N,N-diethoxyphthalimido-5-(substituted phenyl)-3-methyl-1,3a,4,5-tetrahydropyrazolo[3,4-c]pyrazole-4-spiro-5-substituted-1H-indole-2-one 6a-f. The structures of all the synthesized compounds are supported by spectral and analytical data.

Page(s): 885-889

Synthesis and characterization of some novel isoxazolines and pyrazolines as potent antimicrobial agents

Sun, 29 May 2011 22:58:59 GMT

Title: Synthesis and characterization of some novel isoxazolines and pyrazolines as potent antimicrobial agents

Authors: Badadhe, P V; Chavan, N M; Mandhane, P G; Joshi, R S; Nagargoje, D R; Gill, C H

Abstract: The title compounds 4a-h and 5a-h, have been prepared starting from chalcones 3a-h having 5-chlorothiophene moiety. Chalcones 3a-h react with hydroxylamine hydrochloride in presence of alkali to afford isoxazolines 4a-h. Further 3a-h react with hydrazine hydrate in presence of glacial acetic acid to give pyrazolines 5a-h. The structures of newly synthesized compounds have been confirmed by elemental analysis as well as IR, ¹H NMR and mass spectral data. The newly synthesized compounds have been screened for their antimicrobial activity. Some of the compounds show moderate antimicrobial activity as compared to the known reference drugs Gentamycin, Cefixime and Ketoconazole.

Page(s): 879-884

Ceric ammonium nitrate mediated oxidative dimerisation of 1-methoxy naphthalene

Sun, 29 May 2011 22:58:59 GMT

Title: Ceric ammonium nitrate mediated oxidative dimerisation of 1-methoxy naphthalene

Authors: Ramchander, J; Reddy, A Ram

Abstract: Nitration of 1-methoxy naphthalene with cerium (IV) ammonium nitrate in acetic acid gives a complex mixture of six nitro derivatives. Among the six compounds, five are known earlier and one is an unusual new dimer, 1,1′-dimethoxy-4,4′-dinitro-2,2′-binaphthyl, formed by the oxidative biradical coupling. The formation of 1,1′-dimethoxy-4,4′-dinitro-2,2′-binaphthyl is further confirmed by its reduction to 4,4′-diamino-1,1′-dimethoxy-2,2′-binaphthyl.

Page(s): 876-878

Lithium hydroxide catalyzed Michael addition – An easy handling and non-toxic protocol

Sun, 29 May 2011 22:58:59 GMT

Title: Lithium hydroxide catalyzed Michael addition – An easy handling and non-toxic protocol

Authors: Sukanya, Kumari; Deka, Dibakar Chandra

Abstract: Michael addition of dimethyl malonate to α,β-unsaturated ketones are reported in the presence of lithium hydroxide as an efficient catalyst of low toxicity. Moderate to high yield at room temperature is an added advantage of the reaction.

Page(s): 872-875