http://nopr.niscair.res.in/handle/123456789/11396 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/11409 Title: Conventional and microwave induced synthesis of various pyrimidine and isoxazole derivatives from 1-{4'-[(4''-methyl­pipera­zinyl)diazenyl]phenyl}-3-(substituted­phe­nyl)­prop-2-en-1-one and studies of their antimicrobial activity <br/> <br/>Authors: Mistry, B D; Desai, K R; Rana, P B <br/> <br/>Abstract: A series of compounds namely 6-{4'-[(4''-methylpiperazinyl)­diazenyl]phenyl} -4-(substitutedphenyl)-3,4,5-trihydropyrimidin-2-one <b style="">3a-j</b>, 6-{4'-[(4''-methylpiperazinyl) diazenyl]phenyl}-4-(substitutedphenyl)-3,4,5-trihydropyrimidin-2-thione <b style="">4a-j </b>and<b style=""> </b>3-{4'-[(4''-methylpiperazinyl)diazenyl]phenyl}-5-(substituted­phe­nyl)­­­isoxazole <b style="">5a-j</b> have been prepared by the reaction of chalcone derivative 1-{4'-[(4''-methylpiperazinyl)diazenyl] phenyl}-3-(substitutedphenyl)prop-2-en-1-one <b style="">2a-j</b> with urea, thiourea and hydroxylamine hydrochloride respectively. The reactions have been carried out by both microwave and conventional methods. It is noteworthy that the reaction which requires 5-8 hr in conventional method, was completed within 3-6 min by microwave irradiation technique. The microwave-assisted reactions are carried out in a “Q-Pro-M-modified microwave system”. The compounds have been screened for their antimicrobial activities against different microorganisms at 128, 256 and 512 <img src='/image/spc_char/micro.gif' border=0> g/mL. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR,¹H NMR and mass spectral data. <br/> <br/>Page(s): 627-633 Tue, 29 Mar 2011 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/11408 Title: <i>Saussurea heteromalla</i> (D. Don) Hand.-Mazz.: A new source of arctiin, arctigenin and chlorojanerin <br/> <br/>Authors: Saklani, Arvind; Sahoo, Manas Ranjan; Mishra, Prabhu Dutt; Vishwakarma, Ram <br/> <br/>Abstract: <i>Saussurea heteromalla</i> (D. Don) Hand.-Mazz. (Asteraceae), a Himalayan herb, has been investigated phytochemically for the first time in detail and the plant is being reported here as a new source of two lignans, <i style="">i.e</i>. arctigenin and its glycoside arctiin, and one sequiterpene lactone, the chlorojanerin. The structures of these compounds, determined by UV spectra, LC-MS, ¹H NMR and ¹³C NMR spectroscopy are discussed. These compounds have been found pharmacologically important; arctigenin and arctiin are known to have anti-inflammatory activity and chlorjanerin has been investigated for the anti-ulcer and anti-viral properties. <br/> <br/>Page(s): 624-626 Tue, 29 Mar 2011 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/11407 Title: Iodine-catalysed conjugate addition of indole with <img src='/image/spc_char/alpha.gif' border=0> -cinnamylideneketones: Formation of <img src='/image/spc_char/beta.gif' border=0>-(3-indolyl)-<img src='/image/spc_char/alpha.gif' border=0> ,<img src='/image/spc_char/beta.gif' border=0>-dihydro-<img src='/image/spc_char/alpha.gif' border=0> -cinnamylideneketones and bis(3- indolyl)methylbenzene <br/> <br/>Authors: Pal, Rammohan; Mandal, Tapas K; Mallik, Asok K <br/> <br/>Abstract: <img src='/image/spc_char/beta.gif' border=0>-(3-Indolyl)-<img src='/image/spc_char/alpha.gif' border=0> ,<img src='/image/spc_char/beta.gif' border=0>-dihydro-<img src='/image/spc_char/alpha.gif' border=0> -cinnamylideneketones and bis(3-indolyl)methylbenzene have been obtained in moderate to good yield by conjugate addition of indole with <img src='/image/spc_char/alpha.gif' border=0> -cinnamylidene­ketones under mild reaction condition in dry ethanol using iodine as catalyst. The structures of the products have been established from their spectral data. <br/> <br/>Page(s): 619-623 Tue, 29 Mar 2011 22:58:59 GMT http://nopr.niscair.res.in/handle/123456789/11406 Title: Synthesis and evaluation of some novel 1,3,4-thiadiazoles for antidiabetic activity <br/> <br/>Authors: Pattan, S R; Kittur, B S; Sastry, B S; Jadav, S G; Thakur, D K; Madamwar, S A; Shinde, H V <br/> <br/>Abstract: A new series of 1,3,4-thiadiazole derivatives are synthesized and the structures of these compounds have been established on the basis of spectral and elemental analysis. All the compounds<b> </b>are evaluated for antidiabetic activity on albino rats. Most of these compounds show promising antidiabetic activity. <br/> <br/>Page(s): 615-618 Tue, 29 Mar 2011 22:58:59 GMT