NISCAIR Online Periodicals Repository Collection: IJC-B Vol.50B(02) [February 2011]

Synthesis and antimicrobial activity of bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]methanes

Sat, 29 Jan 2011 22:58:59 GMT

Title: Synthesis and antimicrobial activity of bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]methanes

Authors: Reddy, Ch Sanjeeva; Rao, D Chandrashekar; Yakub, V; Nagaraj, A

Abstract: A series of novel bis-[2-imino-3-[5-(3-methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-yl]-5-(arylidene)-1,3-thiazolan-4-one]meth- anes 6a-j have been prepared and their structures confirmed by IR, NMR, MS and elemental analyses. All the synthesized compounds have been tested for their antimicrobial activity against Gram-positive and Gram-negative bacteria, and fungi. Among the synthesized compounds, 6c, 6e, 6f and 6g are found to be the most active against Bacillus subtilis, Bacillus sphaericus, Staphylococcus aureus, Klebsiella aerogenes and Chromobacterium violaceum. Similarly, these compounds show potent antifungal effect against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes.

Page(s): 253-259

An efficient one-pot three component synthesis of new isoxazolyl polyhydroacridine-1,8-diones in an ionic liquid medium

Sat, 29 Jan 2011 22:58:59 GMT

Title: An efficient one-pot three component synthesis of new isoxazolyl polyhydroacridine-1,8-diones in an ionic liquid medium

Authors: Rajanarendar, E; Reddy, M Nagi; Shaik, Firoz Pasha

Abstract: A facile and convenient protocol has been developed for the fast and high yielding one-pot three component synthesis of isoxazolyl polyhydroacridine-1,8-diones from dimedone, aromatic aldehyde and isoxazolyl amine in the presence of ionic liquid [bmim]⁺BF₄^- as an efficient recyclable medium.

Page(s): 245-252

Synthesis of 4-(substituted benzyl)-1H,3H-benzo[f]1,3,5-triazepin-2-ones

Sat, 29 Jan 2011 22:58:59 GMT

Title: Synthesis of 4-(substituted benzyl)-1H,3H-benzo[f]1,3,5-triazepin-2-ones

Authors: Maruthikumar, T Venkata; Rao, G V Panakala; Reddy, V Prabhakar; Rao, P Hanumantha

Abstract: This paper presents the synthesis of 4-(substituted benzyl)-1H,3H-benzo[f]1,3,5-triazepin-2-ones 3 from o-phenylenedi- amines 1 and 4-(arylmethylene)-6-phenyl-3H-1,3,5-oxadiazin-2-ones 2.

Page(s): 242-244

Synthesis and antimalarial activity of novel N-{2-[2-(2-aminoethoxy) ethoxy] ethyl}-7-chloroquinolin-4-amine and its derivatives

Sat, 29 Jan 2011 22:58:59 GMT

Title: Synthesis and antimalarial activity of novel N-{2-[2-(2-aminoethoxy) ethoxy] ethyl}-7-chloroquinolin-4-amine and its derivatives

Authors: Tanwar, Pooja; Yadav, Gyan Chand; Jaitley, U K; Kaushik, Naveen; Sahal, Dinkar

Abstract: A number of N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}-7-chloroquinolin-4-amine derivatives have been prepared by condensation of N-{2-[2-(2-aminoethoxy) ethoxy] ethyl}-7-chloroquinolin-4-amine with substituted aldehyde. The newly synthesized compounds have been characterized by IR, ¹H and ¹³C NMR, and mass spectral data. These compounds have been screened for in vitro antimalarial activity using the Sybr Green assay of P. falciparum in culture and the heme detoxification based Heme-HRP assay. Among these, compounds 7-chloro-N-[2-(2-{2-[(2, 4-difluorobenzyl) amino] ethoxy} ethoxy) ethyl] quinolin-4-amine is found to be the most effective with IC₅₀ value 60 M (in Heme-HRP assay) and 48 nM (in P. falciparum culture assay). These values compare well with the potency of chloroquine in the respective assays.

Page(s): 233-241