http://nopr.niscair.res.in/handle/123456789/792 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/2195 Title: QSAR modeling of thalidomide analogs as antiangiogenic and prostate cancer inhibitor using AM1 calculations <br/> <br/>Authors: Dua, Monica; Revathi, S; Soni, Love Kumar; Gupta, Arun Kumar; Kaskhedikar, S G <br/> <br/>Abstract: Quantitative structure activity relationship studies have been made on thalidomide analogues acting as dual inhibitors of angiogenesis and prostrate cancer using a combination of various electronic, thermodynamic and spatial descriptors. The QSAR studies show that the presence of fluorine atom is essential for both activities. LUMO and partition coefficient play a significant role in antiangiogenic activity while repulsive energy and molar refractivity contribute to anticancer activity. The correlation of inhibitory activity with charge density at 6th, 8th and 16th position of template implies electronic interaction of the molecule with receptor site. <br/> <br/>Page(s): 238-246 http://nopr.niscair.res.in/handle/123456789/981 Title: Studies on hydrolysis of methyl parathion with Zr(IV), Hf(IV) and Cu(II) catalysts in acidic aqueous solutions <br/> <br/>Authors: Algiwale, Tushar Amar; Shinde, C P; Purnanand <br/> <br/>Abstract: Hydrolysis of O,O-dimethyl O-p-nitrophenyl phosphoro-thionate (Methyl Parathion) has been studied in acidic medium with catalysts such as Zr⁴⁺, Hf⁴⁺ and Cu²⁺ cations. In the case of Zr⁴⁺ and Hf⁴⁺ cations, the rate maxima were observed around pH 2.0. Since the metal bound water molecules (M-OH₂) of octameric metal-complex are known to exist in equilibrium with metal-hydroxide ion (M-OH⁻), OH⁻ nucleophiles are abundantly available from these cations even in acidic aqueous solutions. Therefore, an interaction of sulphur of P=S group with metal ion and an intramolecular nucleophilic attack of metal bound OH⁻ at phosphorus atom results in P-O bond cleavage to liberate p-nitrophenol. The 3.2×10⁴ fold rate enhancement with respect to uncatalyzed hydrolysis at pH 6.0 for Cu²⁺ catalysis, has been attributed to high reactivity of hexa-aquo copper complex (i.e., [Cu(H₂O)₆]²⁺), which is known to predominate at around pH 6.0. <br/> <br/>Page(s): 269-272 http://nopr.niscair.res.in/handle/123456789/934 Title: Use of 2,4-undecanedione as a liquid chelating ion exchanger for the recovery of various metal ions <br/> <br/>Authors: Vithlani, Niki; Patel, Anjali <br/> <br/>Abstract: A liquid chelating ion exchanger containing β-diketo group has been synthesized using octanoic acid and characterized by FTIR and UV visible spectroscopy. The synthesized ion exchanger has been used for the extraction of various metal ions such as Ni(II), Zn(II), Cd(II), Co(II), Hg(II) and Ce(II). The concentration of the extracted metal ions has been determined by AAS. The effect of different parameters have been studied and use of 2,4 undecanedione for the removal of mentioned metal ions from industrial effluents, and water from river and domestic water has been proposed. <br/> <br/>Page(s): 290-292 http://nopr.niscair.res.in/handle/123456789/932 Title: Biosorption of hexavalent chromium from aqueous solution by using prawn pond algae (Sphaeroplea) <br/> <br/>Authors: Popuri, Srinivasa R; S, Kalyani; Kachireddy, Suresh R; A, Krishnaiah <br/> <br/>Abstract: Biosorption of chromium (VI) on prawn pond biomass Sphaeroplea algae in natural and acid treated forms has been studied by using batch technique. The equilibrium biosorption level is a function of solution pH, agitation time, initial metal ion concentration and adsorbent dose at room temperature. Both Freundlich and Langmuir adsorption models are suitable for describing the biosorption of chromium (VI) on the two forms of algae while the adsorption process follows the Legergren kinetic model. The biomass has been characterized by FTIR spectra. Surface area values of the biomass are 0.9 and 2.1 m²/g for natural and acid treated forms respectively. At the optimum conditions, the maximum adsorption capacity is found to be 29.8 mg/g and 158.7 mg/g in natural and acid treated forms respectively. <br/> <br/>Page(s): 284-289