http://nopr.niscair.res.in/handle/123456789/7116 Search the Channel search http://nopr.niscair.res.in/simple-search http://nopr.niscair.res.in/handle/123456789/7145 Title: Synthesis of some novel chalcones of phthalimidoester possessing good anti-inflammatory and antimicrobial activity <br/> <br/>Authors: Gaikwad, Kishor V; Gaikwad, Sandip V; Jadhav, Satish B; Rathod, Shantilal D <br/> <br/>Abstract: A new series of methyl-2-[substituted benzylidine]-4-[2-(ph­thalimide) ethoxy] acetoacetate, <b style="">5a-h</b> have been synthesized from the combination of methyl-4-[2-(phthalimido) ethoxy] aceto­acetate, <b style="">3 </b>and substituted benzaldehyde <b style="">4a-h</b> which results in both anti-inflammatory and antimicrobial active compound. These compounds have been characterized by IR, ¹H NMR, mass spectral and elemental analysis. These compounds have been subjected to preliminary anti-inflammatory screening using the carrageenan induced rat pow oedema model. Compounds <b style="">5a,b,c </b>show marked activity comparable to indomethacin. Compounds <b style="">5a,b,c,g</b> show significant antimicrobial activity. <br/> <br/>Page(s): 131-136 http://nopr.niscair.res.in/handle/123456789/7144 Title: A novel access to dispirocyclohexanoneindano pyrrolidines <br/> <br/>Authors: Poornachandran, Mahalingam; Raghunathan, Raghavachary <br/> <br/>Abstract: Synthesis of a series of novel dispirocyclohexanoneindano pyrrolidines has been described. The cycloaddition reaction of azomethine ylide generated from ninhydrin and sarcosine with bisarylidenecyclohexanones was found to be highly region­selective. <br/> <br/>Page(s): 127-130 http://nopr.niscair.res.in/handle/123456789/7143 Title: New cytotoxic saponin of <i>Albizzia lebbeck</i> <br/> <br/>Authors: Jangwan, J S; Dobhal, Maneesha; Kumar, Naveen <br/> <br/>Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="metricconverter"> The methanolic extract of the stem bark of <i>Albizzia lebbeck,</i> a new cytotoxic saponin is isolated and characterized with the help of FABMS, ¹³C NMR and chemical studies. The isolated compound exhibited potent cytotoxic activity against human aqueous cell carcinoma [HSC-2 and HSC-3]. </smarttagtype> <br/> <br/>Page(s): 123-126 http://nopr.niscair.res.in/handle/123456789/7142 Title: Synthesis of 1,3,5-triazinane-2-thiones and 1,3,5-oxadiazinane-4-thiones linked with isoxazoles <br/> <br/>Authors: Rajanarendar, E; Reddy, A Siva Rami; Shaik, Firoz Pasha <br/> <br/>Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="metricconverter"> Trimolecular condensation of <i>N</i>-(3,5-dimethyl-4-isoxazolyl)-<i>N</i>'-arylthioureas <b>2 </b>obtained from<b> 1</b> by reaction with aryliso­thiocyanates, with aqueous formaldehyde and primary amines in toluene under reflux leads to 5-alkyl-1-(3,5-dimethyl-4-iso­xa­zolyl)-3-aryl-hexahydro-1,3,5-triazinane-2-thiones<b> 3 </b>in excellent yields. Condensation of <b>2 </b>with aqueous formaldehyde under similar condition provides isoxazolyl 1,3,5-oxadiazinane-4-thiones <b style="">4</b>. </smarttagtype> <br/> <br/>Page(s): 119-122